Genetic variants related to cell cycle and stability of telomere in patients with glioma

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dc.contributor.authorCalastri, Maria Clara Jessica
dc.contributor.authorHattori, Gabriela
dc.contributor.authorRodrigues, Nicolas Luz Toledo Ortega [UNESP]
dc.contributor.authorGregorio, Michele Lima
dc.contributor.authorBrancati, Camila Ive Ferreira Oliveira
dc.contributor.authorZanovelo, Eliane Milharcix
dc.contributor.authorFilho, José Roberto Lopes Ferraz
dc.contributor.authorNeiva, Cassiano Merussi [UNESP]
dc.contributor.authorJunior, Antonio Carlos Ponde Rodrigues
dc.contributor.authorde Godoy, Moacir Fernandes
dc.contributor.authorLancellotti, Carmen Lucia Penteado
dc.contributor.authorTognola, Waldir Antonio
dc.contributor.authorSouza, Dorotéia Rossi Silva
dc.contributor.institutionSão José do Rio Preto
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMedical School of São José do Rio Preto - HB/FAMERP
dc.contributor.institutionSanta Casa of São Paulo Medical Science College
dc.contributor.institutionMedical School of São José do Rio Preto - FAMERP
dc.date.accessioned2019-10-06T16:45:58Z
dc.date.available2019-10-06T16:45:58Z
dc.date.issued2019-01-01
dc.description.abstractBackground: Glioma, most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Evaluate the association of polymorphisms related of to the cell cycle, integrity and DNA repair with gliomas, as well as lifestyle habits, comorbidities, survival and response to treatment. Methods: Were studied 303 individuals distributed into: Study Group - 100 patients with gliomas, regardless of the degree of malignancy, and Control Group - 203 individuals without clinical signs of the disease. These polymorphisms were genotyped by TaqMan® SNP Genotyping Assay. Significance level was set at 5%. Results: Smoking, alcohol consumption, systemic arterial hypertension (SAH) and diabetes mellitus (DM) prevailed in patients, compared to controls (P=0.0088, P=0.0001, P=0.0001, P=0.0011, respectively). In the logistic regression analysis, alcohol consumption and SAH were identified as independent risk factors for gliomas (P=0.0001, P=0.0027, respectively). Patients with low-grade gliomas showed survival in one year (92.0±6.8%), compared to patients with high-grade gliomas (24.0±5.3; P=0.011). Conclusion: Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas. On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-grade gliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy show increased survival of patients.en
dc.description.affiliationDepartment of Biochemistry and Molecular Biology Faculty of Medicine São José do Rio Preto
dc.description.affiliationDepartament Molecular Biology Sao Paulo State University 'Júlio de Mesquita Filho' Campus- UNESP/IBILCE
dc.description.affiliationDepartament of Patology Hospital de Base University Hospital Medical School of São José do Rio Preto - HB/FAMERP
dc.description.affiliationDepartment of Physical Education Sao Paulo State University 'Júlio de Mesquita Filho' Campus- UNESP/Campos de Bauru
dc.description.affiliationDepartment of Neurology Santa Casa of São Paulo Medical Science College
dc.description.affiliationDepartament of Neurology Medical School of São José do Rio Preto - FAMERP
dc.description.affiliationUnespDepartament Molecular Biology Sao Paulo State University 'Júlio de Mesquita Filho' Campus- UNESP/IBILCE
dc.description.affiliationUnespDepartment of Physical Education Sao Paulo State University 'Júlio de Mesquita Filho' Campus- UNESP/Campos de Bauru
dc.format.extent2345-2351
dc.identifierhttp://dx.doi.org/10.31557/APJCP.2019.20.8.2345
dc.identifier.citationAsian Pacific Journal of Cancer Prevention, v. 20, n. 8, p. 2345-2351, 2019.
dc.identifier.doi10.31557/APJCP.2019.20.8.2345
dc.identifier.issn2476-762X
dc.identifier.issn1513-7368
dc.identifier.scopus2-s2.0-85071746241
dc.identifier.urihttp://hdl.handle.net/11449/189603
dc.language.isoeng
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAstrocytoma
dc.subjectGlioblastoma
dc.subjectMagnetic resonance spectroscopy
dc.subjectPolymorphism
dc.titleGenetic variants related to cell cycle and stability of telomere in patients with gliomaen
dc.typeArtigo
unesp.author.lattes4013645288037489[8]
unesp.author.orcid0000-0003-4413-8207[1]
unesp.author.orcid0000-0003-1635-3209[8]
unesp.departmentEducação Física - FCpt

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Artigos - Biologia - IBILCE
Bauru - FC - Faculdade de Ciências