Clinicopathological analysis of oral mucous autoimmune disease: A 27-year study

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Loschiavo Arisawa, Emilia Angela
Almeida, Janete Dias [UNESP]
Carvalho, Yasmin Rodarte [UNESP]
Guimaraes Cabral, Luiz Antonio [UNESP]

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Medicina Oral S L


Objectives: The aim of the present study was to analyze the main clinical and histopathological features of autoimmune diseases with oral manifestations such as oral lichen planus (OLP); mucous membrane pemphigoid (MMP); pemphigus vulgaris (PV) and erythema multiforme (EM). Study design: Retrospective review of 5770 files from the Oral Pathology Laboratory of Sao Jose dos Campos Dental School, São Paulo State University (UNESP) comprising a 27- year period from 1974 to 2000.Results: The cases accounted for 64 (1.10%) of 5770 anatomopathological examinations performed over the study period. Among the autoimmune diseases diagnosed, 49 (76.56%) were OLP, 6 (9.37%) were MMP, 5 (7.82%) were em and 4 (6.25%) were PV. Descriptive statistical analysis was used.Conclusion: The initial manifestations of most autoimmune diseases occur in the oral mucosa. An earlier diagnosis and proper therapeutic protocol will delay the dissemination of the lesions, thus greatly contributing to a better prognosis and quality of life of the patient.



autoimmune diseases, lichen planus, pemphigoid, mucous membrane, pemphigus, erythema multiforme

Como citar

Medicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 13, n. 2, p. E94-E97, 2008.