Hybrid Membranes of the Ureasil-Polyether Containing Glucose for Future Application in Bone Regeneration

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dc.contributor.authorda Silva, Camila Garcia [UNESP]
dc.contributor.authorMonteiro, João Rodrigues [UNESP]
dc.contributor.authorOshiro-Júnior, João Augusto
dc.contributor.authorChiavacci, Leila Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionState University of Paraiba (UEPB)
dc.date.accessioned2023-07-29T16:14:57Z
dc.date.available2023-07-29T16:14:57Z
dc.date.issued2023-05-01
dc.description.abstractThe application of mesenchymal stem cells (MSC) in bone tissue regeneration can have unpredictable results due to the low survival of cells in the process since the lack of oxygen and nutrients promotes metabolic stress. Therefore, in this work, polymeric membranes formed by organic–inorganic hybrid materials called ureasil-polyether for modified glucose release were developed in order to overcome the problems posed by a of lack of this nutrient. Thus, membranes formed by polymeric blend of polypropylene oxide (PPO4000) and polyethylene oxide (PEO500) with 6% glucose incorporation were developed. Physical–chemical characterization techniques were performed, as well as tests that evaluated thermal properties, bioactivity, swelling, and release in SBF solution. The results of the swelling test showed an increase in membrane mass correlated with an increase in the concentration of ureasil-PEO500 in the polymeric blends. The membranes showed adequate resistance when subjected to the application of a high compression force (15 N). X-ray diffraction (XRD) evidenced peaks corresponding to orthorhombic crystalline organization, but the absence of glucose-related peaks showed characteristics of the amorphous regions of hybrid materials, likely due to solubilization. Thermogravimetry (TG) and differential scanning calorimetry (DSC) analyses showed that the thermal events attributed to glucose and hybrid materials were similar to that seen in the literature, however when glucose was incorporated into the PEO500, an increase in rigidity occurs. In PPO400, and in the blends of both materials, there was a slight decrease in Tg values. The smaller contact angle for the ureasil-PEO500 membrane revealed the more hydrophilic character of the material compared to other membranes. The membranes showed bioactivity and hemocompatibility in vitro. The in vitro release test revealed that it is possible to control the release rate of glucose and the kinetic analysis revealed a release mechanism characteristic of anomalous transport kinetics. Thus, we can conclude that ureasil-polyether membranes have great potential to be used as a glucose release system, and their future application has the potential to optimize the bone regeneration process.en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP
dc.description.affiliationGraduate Program in Pharmaceutical Sciences Biological and Health Sciences Center State University of Paraiba (UEPB), PB
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics15051474
dc.identifier.citationPharmaceutics, v. 15, n. 5, 2023.
dc.identifier.doi10.3390/pharmaceutics15051474
dc.identifier.issn1999-4923
dc.identifier.scopus2-s2.0-85160408677
dc.identifier.urihttp://hdl.handle.net/11449/249997
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.sourceScopus
dc.subjectbone regeneration
dc.subjectglucose release
dc.subjectorganic–inorganic hybrids
dc.subjectpolyethylene oxide
dc.subjectpolypropylene oxide
dc.subjectsol–gel process
dc.titleHybrid Membranes of the Ureasil-Polyether Containing Glucose for Future Application in Bone Regenerationen
dc.typeArtigo
unesp.author.orcid0000-0001-7247-1598[3]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas