Toxin jararhagin in low doses induces interstitial edema and increases the metabolic rate and red blood cells in mice

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dc.contributor.authorFrancisco, Guilherme
dc.contributor.authorZara, Fernando J.
dc.contributor.authorMaria, Durvanei A.
dc.contributor.authorCruz-Neto, Ariovaldo P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.date.accessioned2014-02-26T17:27:43Z
dc.date.accessioned2014-05-20T13:59:13Z
dc.date.available2014-02-26T17:27:43Z
dc.date.available2014-05-20T13:59:13Z
dc.date.issued2006-12-15
dc.description.abstractJararhagin is a metalloproteinase from Bothrops jararaca responsible for hemorrhage, inflammation, necrosis and edema. Effects of low doses of the toxin were analyzed on the energy metabolism of mice as well as its physiological implications. Measures of O-2 consumption (VO2) were quantified after 4 and 24 h of the jarathagin administration during four weeks. Hematocrit and histology of the lungs were also analyzed after the end of the treatment. Results showed that animals that received subcutaneous doses of jararhagin had significant increase in VO2 from second (120 ng) and third weeks (60 ng) after 4 and 24 h, comparing to control, as well as in the number of erythrocytes after four weeks. Histology of the lungs showed interstitial edema within the alveolar septum. Results suggest that the jararhagin toxin caused an increase in VO2 and edema of intra-alveolar septum. The increase of the erythrocytes could be a physiological response to adjust the higher necessity of oxygen, due to diffusional abnormalities caused by the edema. Thus, low doses of jararhagin promote endothelial edema which lead to changes in several physiological conditions. (c) 2006 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Zool, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUNESP, BR-11330900 Sao Vicente, SP, Brazil
dc.description.affiliationInst Butantan, Lab Bioquim & Biofis, BR-05503900 São Paulo, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Zool, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespUNESP, BR-11330900 Sao Vicente, SP, Brazil
dc.format.extent1060-1067
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2006.08.014
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 48, n. 8, p. 1060-1067, 2006.
dc.identifier.doi10.1016/j.toxicon.2006.08.014
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/11449/21063
dc.identifier.wosWOS:000242987700014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectjararhaginpt
dc.subjectmetalloproteinasept
dc.subjectresting metabolic ratept
dc.subjectpulmonary edemapt
dc.subjectmicept
dc.titleToxin jararhagin in low doses induces interstitial edema and increases the metabolic rate and red blood cells in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5758081094133626[4]
unesp.author.orcid0000-0001-5270-7276[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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