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Maternal Passive Immunity and Dengue Hemorrhagic Fever in Infants

dc.contributor.authorAdimy, Mostafa
dc.contributor.authorMancera, Paulo F. A. [UNESP]
dc.contributor.authorRodrigues, Diego S.
dc.contributor.authorSantos, Fernando L. P. [UNESP]
dc.contributor.authorFerreira, Cláudia P. [UNESP]
dc.contributor.institutionUniversité Lyon 1
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2020-12-12T01:12:59Z
dc.date.available2020-12-12T01:12:59Z
dc.date.issued2020-02-01
dc.description.abstractDengue hemorrhagic fever (DHF) can occur in primary dengue virus infection of infants < 1 year of age. To understand the presumed role of maternal dengue-specific antibodies received until birth in the development of this primary DHF in infants, we investigated a mathematical model based on a system of nonlinear ordinary differential equations that mimics cells, virus and antibodies interactions. The neutralization and enhancement activities of maternal antibodies against the virus are represented by a function derived from experimental data and knowledge from the medical literature. The analytic study of the model shows the existence of two equilibriums, a disease-free equilibrium and an endemic one. We performed the asymptotic stability analysis for these two equilibriums. The local asymptotic stability of the endemic equilibrium (DHF equilibrium) corresponds to the occurrence of DHF. Numerical results are also presented in order to illustrate the mathematical analysis performed, highlighting the most important parameters that drive model dynamics. We defined the age at which DHF occurs as the time when the infection takes off that means at the inflection point of the curve of infected cell population. We showed that this age corresponds to the one at which maximum enhancing activity for dengue infection appears. This critical time for the occurrence of DHF is calculated from the model to be approximately 2 months after the time for maternal dengue neutralizing antibodies to degrade below a protective level, which corresponds to what is observed in the experimental data from the literature.en
dc.description.affiliationInria Université de Lyon Université Lyon 1, 43 Bd. du 11 novembre 1918
dc.description.affiliationSão Paulo State University (UNESP), Rua Prof. Dr. Antônio Celso Wagner Zanin, 250, District of Rubião Junior
dc.description.affiliationSchool of Technology University of Campinas (UNICAMP), Rua Paschoal Marmo, 1888
dc.description.affiliationUnespSão Paulo State University (UNESP), Rua Prof. Dr. Antônio Celso Wagner Zanin, 250, District of Rubião Junior
dc.identifierhttp://dx.doi.org/10.1007/s11538-020-00699-x
dc.identifier.citationBulletin of Mathematical Biology, v. 82, n. 2, 2020.
dc.identifier.doi10.1007/s11538-020-00699-x
dc.identifier.issn1522-9602
dc.identifier.issn0092-8240
dc.identifier.lattes2052749698204617
dc.identifier.orcid0000-0002-9404-6098
dc.identifier.scopus2-s2.0-85078410378
dc.identifier.urihttp://hdl.handle.net/11449/198440
dc.language.isoeng
dc.relation.ispartofBulletin of Mathematical Biology
dc.sourceScopus
dc.subjectAntibody-dependent enhancement (ADE)
dc.subjectDENV
dc.subjectLocal and global stability analyses
dc.subjectMathematical modeling
dc.titleMaternal Passive Immunity and Dengue Hemorrhagic Fever in Infantsen
dc.typeArtigo
unesp.author.lattes2052749698204617[5]
unesp.author.orcid0000-0002-9404-6098[5]

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