Sliding mode control in a mathematical model to chemoimmunotherapy: The occurrence of typical singularities
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2020-12-15
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The application of sliding mode control and piecewise smooth vector fields in cancer is an incipient research area. Here we propose a piecewise dynamics to explore chemoimmunotherapeutic strategies. We investigate the dynamic behavior of the discontinuous mathematical model and we observe the occurrence of typical singularities. The on-off treatment strategies are defined in terms of a time-dependent variable such as the number of cancer or immune cells.
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Applied Mathematics and Computation, v. 387.
