Sliding mode control in a mathematical model to chemoimmunotherapy: The occurrence of typical singularities

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dc.contributor.authorRodrigues, Diego S.
dc.contributor.authorMancera, Paulo F.A. [UNESP]
dc.contributor.authorCarvalho, Tiago
dc.contributor.authorGonçalves, Luiz Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2020-12-12T00:56:54Z
dc.date.available2020-12-12T00:56:54Z
dc.date.issued2020-12-15
dc.description.abstractThe application of sliding mode control and piecewise smooth vector fields in cancer is an incipient research area. Here we propose a piecewise dynamics to explore chemoimmunotherapeutic strategies. We investigate the dynamic behavior of the discontinuous mathematical model and we observe the occurrence of typical singularities. The on-off treatment strategies are defined in terms of a time-dependent variable such as the number of cancer or immune cells.en
dc.description.affiliationUNICAMP FT
dc.description.affiliationUNESP IBB
dc.description.affiliationUSP FFCLRP, Ribeirão Preto
dc.description.affiliationUNESP, IBILCE, São José do Rio Preto
dc.description.affiliationUnespUNESP IBB
dc.description.affiliationUnespUNESP, IBILCE, São José do Rio Preto
dc.identifierhttp://dx.doi.org/10.1016/j.amc.2019.124782
dc.identifier.citationApplied Mathematics and Computation, v. 387.
dc.identifier.doi10.1016/j.amc.2019.124782
dc.identifier.issn0096-3003
dc.identifier.scopus2-s2.0-85073559844
dc.identifier.urihttp://hdl.handle.net/11449/198024
dc.language.isoeng
dc.relation.ispartofApplied Mathematics and Computation
dc.sourceScopus
dc.subjectCancer
dc.subjectChemoimmunotherapy
dc.subjectPiecewise smooth vector fields
dc.subjectTypical singularities
dc.titleSliding mode control in a mathematical model to chemoimmunotherapy: The occurrence of typical singularitiesen
dc.typeArtigo
unesp.author.orcid0000-0002-0016-1715[1]
unesp.author.orcid0000-0002-2080-8053[2]
unesp.author.orcid0000-0003-3927-938X[3]
unesp.author.orcid0000-0003-3653-6395[4]

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