Tobacco influence in heavy metals levels in head and neck cancer cases

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dc.contributor.authorBandeira, Celso Muller [UNESP]
dc.contributor.authorde Almeida, Adriana Ávila [UNESP]
dc.contributor.authorCarta, Celina Faig Lima
dc.contributor.authorAlmeida, Alaor Aparecido [UNESP]
dc.contributor.authorde Figueiredo, Fellipe Augusto Tocchini [UNESP]
dc.contributor.authorSandrim, Valeria Cristina [UNESP]
dc.contributor.authorGonçalves, Antonio José
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity Braz Cubas
dc.contributor.institutionIrmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)
dc.date.accessioned2018-12-11T17:22:00Z
dc.date.available2018-12-11T17:22:00Z
dc.date.issued2018-09-01
dc.description.abstractHeavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Sao Paulo State University (Unesp) Institute of Science and Technology, Av. Eng. Francisco José Longo 777
dc.description.affiliationMogi das Cruzes University Braz Cubas
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Sao Paulo State University (Unesp) Institute of Biosciences of Botucatu
dc.description.affiliationDepartment of Pharmacology Sao Paulo State University (Unesp) Institute of Biosciences of Botucatu
dc.description.affiliationDepartment of Head and Neck Surgery Medical Sciences College Irmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP)
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Sao Paulo State University (Unesp) Institute of Science and Technology, Av. Eng. Francisco José Longo 777
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Sao Paulo State University (Unesp) Institute of Biosciences of Botucatu
dc.description.affiliationUnespDepartment of Pharmacology Sao Paulo State University (Unesp) Institute of Biosciences of Botucatu
dc.format.extent27650-27656
dc.identifierhttp://dx.doi.org/10.1007/s11356-018-2668-9
dc.identifier.citationEnvironmental Science and Pollution Research, v. 25, n. 27, p. 27650-27656, 2018.
dc.identifier.doi10.1007/s11356-018-2668-9
dc.identifier.file2-s2.0-85050926786.pdf
dc.identifier.issn1614-7499
dc.identifier.issn0944-1344
dc.identifier.scopus2-s2.0-85050926786
dc.identifier.urihttp://hdl.handle.net/11449/176668
dc.language.isoeng
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.relation.ispartofsjr0,858
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCarcinoma, squamous cell
dc.subjectHead and neck neoplasms
dc.subjectMetals, heavy
dc.subjectTobacco
dc.titleTobacco influence in heavy metals levels in head and neck cancer casesen
dc.typeArtigo
unesp.author.orcid0000-0003-4596-9715[8]

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Botucatu - CEATOX - Centro de Assistência Toxicológica
Artigos - Farmacologia - IBB