Acute mucociliary clearance response to aerobic exercise in smokers

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dc.contributor.authorRamos, Ercy M. C. [UNESP]
dc.contributor.authorVanderlei, Luiz Carlos M.
dc.contributor.authorIto, Juliana T.
dc.contributor.authorLima, Fabiano F.
dc.contributor.authorRodrigues, Fernanda Mm
dc.contributor.authorManzano, Beatriz M.
dc.contributor.authorFernandes, Rômulo A. [UNESP]
dc.contributor.authorCecílio, Michel J.
dc.contributor.authorToledo-Arruda, Alessandra C.
dc.contributor.authorRamos, Dionei
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-12-07T15:34:13Z
dc.date.available2015-12-07T15:34:13Z
dc.date.issued2015
dc.description.abstractMucociliary clearance is the main defense mechanism of the respiratory system, and it is influenced by several stimuli, including aerobic exercise and cigarette smoking. We evaluated the acute response of mucociliary clearance to aerobic exercise in smokers and nonsmokers compared with that found after acute smoking and smoking combined with exercise. Also, we investigated whether there was a correlation between mucociliary clearance and the autonomic nervous system under these conditions. Twenty-one smokers were evaluated for mucociliary clearance by saccharin transit time (STT), and the response of the autonomic nervous system was evaluated by heart rate variability after aerobic exercise, after exercise followed by smoking, after acute smoking, and after rest. For comparison, 17 nonsmokers were also assessed during exercise. Repeated-measures analysis of variance with the Tukey test or the Friedman test followed by the Dunn test was used to evaluate the STT, autonomic response, and other variables to exercise and/or smoking in smokers. A paired t test or Wilcoxon test was used to analyze responses to exercise in nonsmokers. Correlations were evaluated using Pearson or Spearman coefficients. The STT was reduced after exercise in both groups, with similar responses between them. Other stimuli also reduced the STT. The STT showed a negative correlation with sympathetic activity in smokers and a positive correlation with the parasympathetic system in nonsmokers. Although impaired in smokers, mucociliary clearance responded to the stimulus of exercise, as demonstrated by similar STTs compared with nonsmokers. This response was correlated with the autonomic nervous system in both groups. In smokers, mucociliary clearance also responded to the stimuli of smoking and exercise followed by smoking.en
dc.description.affiliationDepartment of Pulmonology, Universidade Federal de São Paulo (UNIFESP)/Escola Paulista de Medicina (EPM), São Paulo, São Paulo, Brazil
dc.description.affiliationDepartment of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo, Brazil
dc.description.affiliationDepartment of Medicine, Universidade do Oeste Paulista (UNOESTE), Presidente Prudente, São Paulo, Brazil.
dc.description.affiliationDepartment of Clinical Medicine, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, São Paulo, Brazil
dc.description.affiliationUnespDepartment of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo, Brazil.
dc.description.sponsorshipPró-Reitoria de Extensão Universitária (PROEX)/Universidade Estadual Paulista (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2012/09932-0
dc.description.sponsorshipIdFAPESP: 2012/04699-6
dc.description.sponsorshipIdCNPq: 2012/484658
dc.format.extent1575-1584
dc.identifierhttp://dx.doi.org/10.4187/respcare.04093
dc.identifier.citationRespiratory Care, v. 60, n. 11, p. 1575-1584, 2015.
dc.identifier.doi10.4187/respcare.04093
dc.identifier.issn1943-3654
dc.identifier.lattes1470583417166740
dc.identifier.pubmed26264417
dc.identifier.urihttp://hdl.handle.net/11449/131350
dc.language.isoeng
dc.publisherDaedalus Enterprises.
dc.relation.ispartofRespiratory Care
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAerobic exerciseen
dc.subjectAirwayen
dc.subjectAutonomic nervous systemen
dc.subjectMucociliary clearanceen
dc.subjectPhysical exerciseen
dc.subjectSmokingen
dc.titleAcute mucociliary clearance response to aerobic exercise in smokersen
dc.typeArtigo
dcterms.rightsHolderCopyright © 2015 by Daedalus Enterprises.Copyright © 2015 By Daedalus Enterprises.
unesp.author.lattes1470583417166740
unesp.author.orcid0000-0002-1891-3153[2]
unesp.author.orcid0000-0002-3310-7336[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept

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