Prenatal exposure to sertraline, associated or not with stress, can negatively program somatic and neurobehavioral development of female rats, and dysregulate reproductive function in adulthood

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dc.contributor.authorMoura, Mayara Silva [UNESP]
dc.contributor.authorLozano, Ana Flávia Quiarato [UNESP]
dc.contributor.authorTavares, Bruna Marques [UNESP]
dc.contributor.authorFigueiredo, Thamíris Moreira [UNESP]
dc.contributor.authorFranco de Barros, Jorge Willian [UNESP]
dc.contributor.authorValencise, Lethicia [UNESP]
dc.contributor.authorde Grava Kempinas, Wilma [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:04:18Z
dc.date.available2023-07-29T16:04:18Z
dc.date.issued2023-03-01
dc.description.abstractSelective serotonin reuptake inhibitors (SSRIs) are prescribed to pregnant women for treating mental illnesses. Among the drugs of this class, sertraline (ST) is the antidepressant therapy recommended most frequently. Therefore, this study aimed to evaluate the impact of gestational ST treatment on reproductive parameters and toxicological target organs of rat female offspring, as well as on somatic, reflex and neurobehavioral development, in a model of maternal adversity. Pregnant Wistar rats received vehicle (filtered water) or ST hydrochloride (20 mg/Kg/day diluted in vehicle) by oral gavage, associated or not with restraint stress for 1 h/day from gestational days 13–20. F1 female offspring was evaluated on reproductive parameters, body weight and somatic and reflex milestones from postnatal day (PND) 1. On PNDs 25 and 72, the elevated-plus-maze test was performed, while toxicological target organs were evaluated on PNDs 42 and 80. In utero exposure to ST, regardless of exposure to stress, reduced body weight at birth and affected the somatic development and estrous cycle. The absolute and relative thyroid weights were increased in Stress/ST group during puberty and adulthood, while the percentage of ovarian structures and the absolute uterine weight were altered in this group on PND 80. Prenatal exposure only to ST reduced initial body weight gain, delayed fur development and increased anxiety-like behavior on PND 25. Thus, this experimental study suggests that intrauterine exposure to ST disrupts the fetal environment and can negatively program serotonin-regulated processes. Furthermore, it impacts thyroid weight when associated with stress.en
dc.description.affiliationGraduate Program in General and Applied Biology São Paulo State University (UNESP) Institute of Biosciences, SP
dc.description.affiliationLaboratory of Reproductive and Developmental Biology and Toxicology Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP
dc.description.affiliationUnespGraduate Program in General and Applied Biology São Paulo State University (UNESP) Institute of Biosciences, SP
dc.description.affiliationUnespLaboratory of Reproductive and Developmental Biology and Toxicology Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 312118/2017-1
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2023.108336
dc.identifier.citationReproductive Toxicology, v. 116.
dc.identifier.doi10.1016/j.reprotox.2023.108336
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85146893671
dc.identifier.urihttp://hdl.handle.net/11449/249604
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.sourceScopus
dc.subjectFetal programming
dc.subjectNeurodevelopment
dc.subjectPrenatal stress
dc.subjectReproductive toxicology
dc.subjectSertraline
dc.titlePrenatal exposure to sertraline, associated or not with stress, can negatively program somatic and neurobehavioral development of female rats, and dysregulate reproductive function in adulthooden
dc.typeArtigo

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