A Review of the Role of Flavonoids in Peptic Ulcer (2010-2020)

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dc.contributor.authorSerafim, Catarina
dc.contributor.authorAraruna, Maria Elaine
dc.contributor.authorJunior, Edvaldo Alves
dc.contributor.authorDiniz, Margareth
dc.contributor.authorHiruma-Lima, Clelia [UNESP]
dc.contributor.authorBatista, Leonia
dc.contributor.institutionUniv Fed Paraiba
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T12:26:56Z
dc.date.available2021-06-25T12:26:56Z
dc.date.issued2020-11-01
dc.description.abstractPeptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that may reach the muscle layer. Their etiology is multifactorial and occurs when the balance between offensive and protective factors of the mucosa is disturbed. Peptic ulcers represent a global health problem, affecting millions of people worldwide and showing high rates of recurrence. Helicobacter pylori infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most important predisposing factors for the development of peptic ulcers. Therefore, new approaches to complementary treatments are needed to prevent the development of ulcers and their recurrence. Natural products such as medicinal plants and their isolated compounds have been widely used in experimental models of peptic ulcers. Flavonoids are among the molecules of greatest interest in biological assays due to their anti-inflammatory and antioxidant properties. The present study is a literature review of flavonoids that have been reported to show peptic ulcer activity in experimental models. Studies published from January 2010 to January 2020 were selected from reference databases. This review refers to a collection of flavonoids with antiulcer activity in vivo and in vitro models.en
dc.description.affiliationUniv Fed Paraiba, Hlth Sci Ctr, Postgrad Program Nat Prod & Bioact Synthet, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, Hlth Sci Ctr, Dept Pharm, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol Physiol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol Physiol, BR-18618970 Botucatu, SP, Brazil
dc.format.extent32
dc.identifierhttp://dx.doi.org/10.3390/molecules25225431
dc.identifier.citationMolecules. Basel: Mdpi, v. 25, n. 22, 32 p., 2020.
dc.identifier.doi10.3390/molecules25225431
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.urihttp://hdl.handle.net/11449/209719
dc.identifier.wosWOS:000594166600001
dc.language.isoeng
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.sourceWeb of Science
dc.subjectflavonoids
dc.subjectpeptic ulcer
dc.subjectreview
dc.titleA Review of the Role of Flavonoids in Peptic Ulcer (2010-2020)en
dc.typeResenha
dcterms.rightsHolderMdpi
unesp.author.lattes3814504901386844[5]
unesp.author.orcid0000-0002-8645-3777[5]

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