Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration
| dc.contributor.author | Vassilieff, I. | |
| dc.contributor.author | De Oliveira Vassilieff, V. S. | |
| dc.contributor.author | Chagas, A. M. | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.date.accessioned | 2022-04-29T08:42:01Z | |
| dc.date.available | 2022-04-29T08:42:01Z | |
| dc.date.issued | 1979-12-01 | |
| dc.description.abstract | Methoxyflurane (0.2 ml/kg over 5 min), administered by inhalation to dogs with spontaneous respiration, resulted approximately 10 minutes later in a significant increase of intraocular pressure (IOP) (13.3 mm Hg), cerebrospinal fluid pressure (CSFP) (9.4 mm Hg), and venous pressure (VP) (6 mm Hg), as well as a significant decrease in arterial pressure (AP) (23.3 mm Hg), respiratory frequency (3.2 mov/min) and respiratory amplitude (7.1 mm). These alterations occurred concomitantly with respiratory acidosis, an increase in serum K+ and Cl-, increased osmolarity of the aqueous humor, and an elevation of K+ and Cl- in cerebrospinal fluid (CSF). However, if CSF was allowed to drain freely so that no increase of CSFP occurred, there was only a small increase of IOP (3.7 mm Hg). Under these latter conditions, there also was a decrease of arterial pressure (20.7 mm Hg), respiratory frequency (9.5 mov/min) and respiratory amplitude (2.1 mm). When dogs were ventilated artificially the above changes were greatly attenuated. They were limited to a small but significant rise of CSFP (4.7 mm Hg), a decrease in AP (20.7 mm Hg) and a decrease of HCO3- (7.6 mEq/) of arterial blood. The possible mechanisms involved in the action of methoxyflurane on IOP were discussed and it was pointed out that this anesthetic agent might be used for inducing anesthesia; however, it would be necessary to avoid respiratory depression, in order to prevent intracranial and ocular hypertension. | en |
| dc.description.affiliation | Dept. Farmacol., Inst. Bas. Biol., Med. Agric. Campus Botucatu, Univ. Estad. Paulista Julio de Mesquita Filho, Botucatu | |
| dc.format.extent | 33-39 | |
| dc.identifier.citation | Brazilian Journal of Medical and Biological Research, v. 12, n. 1, p. 33-39, 1979. | |
| dc.identifier.issn | 0100-879X | |
| dc.identifier.scopus | 2-s2.0-0018778575 | |
| dc.identifier.uri | http://hdl.handle.net/11449/230792 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Brazilian Journal of Medical and Biological Research | |
| dc.source | Scopus | |
| dc.title | Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration | en |
| dc.type | Artigo |