HIV-related plasmablastic lymphoma causing extensive bone destruction in the mandible

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dc.contributor.authorKayahara, Giseli Mitsuy [UNESP]
dc.contributor.authorValente, Vitor Bonetti [UNESP]
dc.contributor.authorSalzedas, Leda Maria Pescinini [UNESP]
dc.contributor.authorPassador-Santos, Fabrício
dc.contributor.authorFuruse, Cristiane [UNESP]
dc.contributor.authorBiasoli, Éder Ricardo [UNESP]
dc.contributor.authorMiyahara, Glauco Issamu [UNESP]
dc.contributor.authorBernabé, Daniel Galera [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSão Leopoldo Mandic Research Institute
dc.date.accessioned2022-04-29T08:39:26Z
dc.date.available2022-04-29T08:39:26Z
dc.date.issued2022-03-01
dc.description.abstractPlasmablastic lymphoma (PBL) is a rare subtype of large B-cell lymphoma commonly associated with HIV infection. HIV-related PBL has a dismal prognosis. The aggressive clinical course of the disease may lead to the development of rapid-growing swellings, like several benign and malignant conditions. Herein, we reported the case of a 38-year-old woman with a painful swelling in the mandible initially diagnosed as an abscess derived from a tooth extraction. Intraoral examination revealed a painful swelling with reddish, white and purplish areas in the posterior region of the mandible without signs of infection. Imaging exams showed an extensive bone destruction in the left mandibular body. Histopathological examination revealed a high proliferation of plasmacytoid cells with nuclear hyperchromatism. Tumor cells were negative for CD20, and positive for Ki-67, CD138, IgG and lambda chain. The diagnosis of oral PBL was defined and serological test showed positivity for HIV. Eight months after starting treatment, the patient died due to complications of cancer treatment. Lymphoproliferative malignancies related to HIV infection should be included in the differential diagnosis of rapid-growing swellings in the oral cavity.en
dc.description.affiliationOral Oncology Center São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St São Paulo
dc.description.affiliationDepartment of Diagnosis and Surgery São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St São Paulo
dc.description.affiliationDepartment of Oral Pathology São Leopoldo Mandic Research Institute, 13 José Rocha Junqueira St São Paulo
dc.description.affiliationUnespOral Oncology Center São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St São Paulo
dc.description.affiliationUnespDepartment of Diagnosis and Surgery São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St São Paulo
dc.identifierhttp://dx.doi.org/10.1016/j.oraloncology.2022.105761
dc.identifier.citationOral Oncology, v. 126.
dc.identifier.doi10.1016/j.oraloncology.2022.105761
dc.identifier.issn1879-0593
dc.identifier.issn1368-8375
dc.identifier.scopus2-s2.0-85124206603
dc.identifier.urihttp://hdl.handle.net/11449/230352
dc.language.isoeng
dc.relation.ispartofOral Oncology
dc.sourceScopus
dc.subjectBone lesions
dc.subjectCancer
dc.subjectDiagnosis
dc.subjectHIV
dc.subjectLymphoma
dc.subjectLymphoproliferative malignancies
dc.subjectMalignant tumor
dc.subjectNon-Hodking's lymphoma
dc.subjectOral plasmablastic lymphoma
dc.subjectPlasmablastic lymphoma
dc.titleHIV-related plasmablastic lymphoma causing extensive bone destruction in the mandibleen
dc.typeCarta

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