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DNA gains at 8q23.2: a potential early marker in head and neck carcinomas

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dc.contributor.authorVeiga, LCD
dc.contributor.authorBergamo, N. A.
dc.contributor.authordos Reis, P. P.
dc.contributor.authorKowalski, L. P.
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHosp AC Camargo Fund Antonio Prudente
dc.date.accessioned2014-05-20T13:50:10Z
dc.date.available2014-05-20T13:50:10Z
dc.date.issued2003-10-15
dc.description.abstractGains or amplifications involving chromosome arm 8q are one of the most recurrent chromosomal alterations in head and neck tumors. To characterize previously reported gains, we performed fluorescence in situ hybridization (FISH) using the sequences BAC RP1179E1 and 8-centromere PMJ 128 as probes. Gains and/or amplifications were detected in all 19 cases evaluated by FISH. The FISH analysis, but not G-banding, revealed homogeneously staining region in three cases. We conclude that gains of one or more genes on chromosome arm 8q may be important for the early stages of head and neck carcinomas. (C) 2003 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Genet, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationHosp AC Camargo Fund Antonio Prudente, Dept Cirurgia Cabeca Pescoco, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Genet, BR-18618000 Botucatu, SP, Brazil
dc.format.extent110-115
dc.identifierhttp://dx.doi.org/10.1016/S0165-4608(03)00132-8
dc.identifier.citationCancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 146, n. 2, p. 110-115, 2003.
dc.identifier.doi10.1016/S0165-4608(03)00132-8
dc.identifier.issn0165-4608
dc.identifier.urihttp://hdl.handle.net/11449/17913
dc.identifier.wosWOS:000185933400003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Genetics and Cytogenetics
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleDNA gains at 8q23.2: a potential early marker in head and neck carcinomasen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentGenética - IBBpt

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Botucatu - IBB - Instituto de Biociências