Laser surgery in management of medication-related osteonecrosis of the jaws: a meta-analysis

dc.contributor.authorMomesso, Gustavo Antonio Correa [UNESP]
dc.contributor.authorLemos, Cleidiel Aparecido Araújo [UNESP]
dc.contributor.authorSantiago-Júnior, Joel Ferreira
dc.contributor.authorFaverani, Leonardo Perez [UNESP]
dc.contributor.authorPellizzer, Eduardo Piza [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSacred Heart University (USC)
dc.date.accessioned2020-12-12T02:36:05Z
dc.date.available2020-12-12T02:36:05Z
dc.date.issued2020-06-01
dc.description.abstractPurpose: The aim of this study was to perform a systematic review and meta-analysis to evaluate the efficacy of laser therapy on medication-related osteonecrosis of the jaw (MRONJ) treatment. Methods: This study followed PRISMA standards, and an electronic search was performed on the PubMed/MEDLINE, Scopus, and Cochrane databases. Eighty-nine articles were found. After reading the manuscripts, 15 articles remained for the review. Three of them were selected for meta-analysis. Results: Female gender was predominant (72.5%), and mean age was 66.5 years. Follow-up varied between 3 and 80 months, and the most used bisphosphonate was zoledronic acid (71.6%). Stage II of MRONJ was the most prevalent (68.9%), and the mandible was the most affected site (64.5%). Qualitative data showed that treatment with laser surgery (Er:YAG) was most effective regarding complete healing of the lesion (90%) compared with other treatments. Meta-analysis data showed that low-level laser therapy (LLLT) was more effective than medical treatment (P = 0.006), and surgical treatment was more effective than LLLT (P = 0.008). Conclusion: Laser surgery was significantly superior to LLLT (p < 0.00001). Therefore, laser surgical therapy seems to be a great management strategy for MRONJ treatment from stage II. LLLT was shown to improve conservative management in earlier MRONJ stages.en
dc.description.affiliationDepartment of Diagnosis and Surgery Aracatuba Dental School São Paulo State University (UNESP)
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Health Sciences Sacred Heart University (USC)
dc.description.affiliationUnespDepartment of Diagnosis and Surgery Aracatuba Dental School São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.format.extent133-144
dc.identifierhttp://dx.doi.org/10.1007/s10006-020-00831-0
dc.identifier.citationOral and Maxillofacial Surgery, v. 24, n. 2, p. 133-144, 2020.
dc.identifier.doi10.1007/s10006-020-00831-0
dc.identifier.issn1865-1569
dc.identifier.issn1865-1550
dc.identifier.scopus2-s2.0-85079710202
dc.identifier.urihttp://hdl.handle.net/11449/201569
dc.language.isoeng
dc.relation.ispartofOral and Maxillofacial Surgery
dc.sourceScopus
dc.subjectBisphosphonate
dc.subjectLaser therapy
dc.subjectLow-level laser therapy
dc.subjectMedication-associated osteonecrosis of the jaw
dc.titleLaser surgery in management of medication-related osteonecrosis of the jaws: a meta-analysisen
dc.typeResenha

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