Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: A pilot study

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dc.contributor.authorLima, Emerson V.A.
dc.contributor.authorLima, Mariana Modesto D.A.
dc.contributor.authorPaixão, Mauricio Pedreira
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.institutionSanta Casa de Misericórdia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:16:21Z
dc.date.available2018-12-11T17:16:21Z
dc.date.issued2017-11-28
dc.description.abstractBackground: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. Methods: Open pilot trial including six women with facial refractory melasma submitted to two sessions of microneedling (1.5 mm) each 30 days followed by daily triple combination and broad-spectrum sunscreen. Comparison of pretreatment (T0) and 15 days after last microneedling procedure (T45) was made by standardized pictures, skin colorimetry, MASI, MELASQoL and histological parameters (haematoxylin-eosin, picrosirius-red, periodic acid Schiff and Fontana-Masson staining). Results: The age of the subjects varied from 34 to 46 years-old, the phototypes were III and IV (Fitzpatrick), and age of melasma onset was 20 to 38 years. Improvement of melasma was perceived in all subjects. There was a significant reduction of MASI score (-70%), MELASQoL (-55%) and increase in L* (+13%) colorimetric value (p < 0.03). All cases evidenced epithelium thickening, decrease in melanin pigmentation and densification of upper dermis collagen (p = 0.03). Patients were followed by 6 months under broad-spectrum sunscreen and triple combination without relapse. Conclusion: In addition to classic treatment (broad-spectrum sunscreen and triple combination), skin microneedling promoted clinical and histological improvement of refractory facial melasma.en
dc.description.affiliationSanta Casa de Misericórdia, Praça Fleming, 35/1201 Jaqueira
dc.description.affiliationUNIFESP
dc.description.affiliationUnesp Medical School
dc.description.affiliationCampus da Unesp Departamento de Dermatologia SN
dc.description.affiliationUnespUnesp Medical School
dc.description.affiliationUnespCampus da Unesp Departamento de Dermatologia SN
dc.identifierhttp://dx.doi.org/10.1186/s12895-017-0066-5
dc.identifier.citationBMC Dermatology, v. 17, n. 1, 2017.
dc.identifier.doi10.1186/s12895-017-0066-5
dc.identifier.file2-s2.0-85035325709.pdf
dc.identifier.issn1471-5945
dc.identifier.scopus2-s2.0-85035325709
dc.identifier.urihttp://hdl.handle.net/11449/175570
dc.language.isoeng
dc.relation.ispartofBMC Dermatology
dc.relation.ispartofsjr0,796
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectMasi
dc.subjectMelasma
dc.subjectMicroneedling
dc.subjectQuality of life
dc.subjectTreatment
dc.titleAssessment of the effects of skin microneedling as adjuvant therapy for facial melasma: A pilot studyen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

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