A novel Ag doping Ti alloys route: Formation and antibacterial effect of the TiO2 nanotubes

Página do item simplificado
dc.contributor.authorTaipina, Márcia O.
dc.contributor.authorde Mello, Mariana G.
dc.contributor.authorTamborlin, Leticia [UNESP]
dc.contributor.authorPereira, Karina D. [UNESP]
dc.contributor.authorLuchessi, Augusto D. [UNESP]
dc.contributor.authorCremasco, Alessandra
dc.contributor.authorCaram, Rubens
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:19:09Z
dc.date.available2021-06-25T10:19:09Z
dc.date.issued2021-03-01
dc.description.abstractTitanium has been widely used for clinical purposes, but post-surgical infections remain a troublesome issue, impairing patient's quality of life. Silver (Ag) is a potent broad-spectrum antimicrobial agent whose disinfecting effect has been known for centuries. In light of this fact, as an attempt to provide a long-term solution to prevent implant-associated infection, we produced Ti–35Nb alloys containing Ag, using different methods to incorporate it. These alloys were subjected to an electrochemical process to produce TiO2 nanotubes on their surface, in an attempt to further improve the material's bioactivity. Also, on the Ti–35Nb substrate, TiO2 nanotubes were grown and then decorated with Ag by UV light-induced photoreduction. The results indicate that Ag does not affect the formation of TiO2 arrays. Furthermore, the results show that added Ag can elicit antibacterial activity without leaching significant amounts of Ag that are considered toxic to mammalian cells. An initial cytotoxicity evaluation was conducted with pre-osteoblast cell line (MC3T3-E1) and its viability profile was indirectly assessed by MTT assay. Results indicate that the presence of TiO2 improves osteoblast proliferation and that Ag addition seems to mostly promote cell proliferation.en
dc.description.affiliationUniversity of Campinas (UNICAMP) School of Mechanical Engineering Campinas
dc.description.affiliationUniversity of Campinas (UNICAMP) School of Applied Sciences Limeira
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCentro Nacional de Pesquisa em Energia e Materiais
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipLaboratório Nacional de Nanotecnologia
dc.description.sponsorshipIdFAPESP: 2014/00159-2
dc.description.sponsorshipIdFAPESP: 2016/24693-3
dc.description.sponsorshipIdFAPESP: 2017/21914-1
dc.description.sponsorshipIdFAPESP: 2019/06951-3
dc.description.sponsorshipIdCNPq: 405054/2016-5
dc.description.sponsorshipIdCAPES: 88887.357955/2019–00
dc.identifierhttp://dx.doi.org/10.1016/j.matchemphys.2020.124192
dc.identifier.citationMaterials Chemistry and Physics, v. 261.
dc.identifier.doi10.1016/j.matchemphys.2020.124192
dc.identifier.issn0254-0584
dc.identifier.scopus2-s2.0-85098561446
dc.identifier.urihttp://hdl.handle.net/11449/205658
dc.language.isoeng
dc.relation.ispartofMaterials Chemistry and Physics
dc.sourceScopus
dc.subjectAg
dc.subjectBactericidal effect
dc.subjectBiomaterial application
dc.subjectCell proliferation
dc.subjectTiO2 nanotubes
dc.titleA novel Ag doping Ti alloys route: Formation and antibacterial effect of the TiO2 nanotubesen
dc.typeArtigo
unesp.author.orcid0000-0003-1140-2841 0000-0003-1140-2841[3]
unesp.author.orcid0000-0001-9424-6682 0000-0001-9424-6682[4]

Arquivos

Coleções

Artigos