Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats

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dc.contributor.authorAzevedo, Paula S. [UNESP]
dc.contributor.authorPolegato, Bertha F. [UNESP]
dc.contributor.authorMinicucci, Marcos F. [UNESP]
dc.contributor.authorPio, Stephan M. [UNESP]
dc.contributor.authorSilva, Igor A. [UNESP]
dc.contributor.authorSantos, Priscila P. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorPaiva, Sergio A. R. [UNESP]
dc.contributor.authorZornoff, Leonardo A. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T04:10:42Z
dc.date.available2022-04-29T04:10:42Z
dc.date.issued2012-01-01
dc.description.abstractBackground: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model. Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI. Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; CI 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6±1.8 mmHg in the control group and 9.4±7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm2 for ESA, 40% for FAC, and 26 mm/s for PWSV. Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion. © Med Sci Monit.en
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School UNESP, Botucatu
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School UNESP, Botucatu
dc.identifierhttp://dx.doi.org/10.12659/MSM.883202
dc.identifier.citationMedical Science Monitor, v. 18, n. 7, 2012.
dc.identifier.doi10.12659/MSM.883202
dc.identifier.issn1643-3750
dc.identifier.issn1234-1010
dc.identifier.scopus2-s2.0-84863793066
dc.identifier.urihttp://hdl.handle.net/11449/226893
dc.language.isoeng
dc.relation.ispartofMedical Science Monitor
dc.sourceScopus
dc.subjectCardiac function
dc.subjectHeart failure
dc.subjectRemodelingbr
dc.titleEarly echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in ratsen
dc.typeArtigo

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