V-ATPases and Their Implication in Oral Cancer

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dc.contributor.authorOliveira Alves, Monica Ghislaine [UNESP]
dc.contributor.authorGarcia-Garcia, Abel
dc.contributor.authorPerez-Sayans, Mario
dc.contributor.authorChakraborti, S.
dc.contributor.authorDhalla, N. S.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFac Med & Dent
dc.date.accessioned2023-07-29T11:53:06Z
dc.date.available2023-07-29T11:53:06Z
dc.date.issued2016-01-01
dc.description.abstractThe control of intracellular and extracellular pH is extremely important for many biological functions and the condition of hypoxia is a frequent phenomenon during the development of oral squamous cell carcinoma (OSCC). The cellular acidosis appears to be controlled, mainly, by the vacuolar-type H+ ATPase (V-ATPase), which is clearly involved in cellular transformation during carcinogenesis and metastasis. The C subunit (ATP6V1C) of V1 intra-membrane domain of the V-ATPase is primarily responsible for its enzymatic function, through the control of a reversible dissociation of VO and V1 domains. It is observed a high overexpression of the gene ATP6V1C 1 in OSCC, this tumor cells exhibited high metabolic activity and the active mechanisms capable of pumping protons from the cell interior are necessary. The acidification of the extracellular environment resulting from poor vascularization and cell metabolism promotes the activity of proteolytic enzymes that contribute to tumor invasiveness and metastasis. In the future, V-ATPase inhibitor molecules could be used in cancer treatment through the mensuration of the overexpression of specific V-ATPase subunits in tumors to be treated and, then, using specific inhibitors for the subunits being expressed. This will allow clinicians to provide more specific treatment, while also minimizing adverse effects.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Inst Sci & Technol, 777 Engn Francisco Jose Longo Ave, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationFac Med & Dent, Oral Med Oral Surg & Implantol Unit, Entrerrios S-N, Santiago De Compostela 15782, Acoruna, Spain
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Inst Sci & Technol, 777 Engn Francisco Jose Longo Ave, Sao Jose Dos Campos, SP, Brazil
dc.format.extent393-405
dc.identifierhttp://dx.doi.org/10.1007/978-3-319-24780-9_19
dc.identifier.citationRegulation of Ca2+-atpases, V-atpases and F-atpases. New York: Springer, v. 14, p. 393-405, 2016.
dc.identifier.doi10.1007/978-3-319-24780-9_19
dc.identifier.urihttp://hdl.handle.net/11449/245377
dc.identifier.wosWOS:000369377300020
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofRegulation Of Ca2+-atpases, V-atpases And F-atpases
dc.sourceWeb of Science
dc.subjectOral squamous cell carcinoma
dc.subjectATP6V1C1
dc.subjectCancer
dc.subjectV-ATPase inhibitors
dc.subjectTumor metastasis
dc.subjectChemoresistance
dc.titleV-ATPases and Their Implication in Oral Canceren
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0002-5911-5537[2]

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