Green and chemical silver nanoparticles and pomegranate formulations to heal infected wounds in diabetic rats

dc.contributor.authorScappaticci, Renan Aparecido Fernandes [UNESP]
dc.contributor.authorBerretta, Andresa Aparecida
dc.contributor.authorTorres, Elina Cassia
dc.contributor.authorBuszinski, Andrei Felipe Moreira
dc.contributor.authorFernandes, Gabriela Lopes [UNESP]
dc.contributor.authorDos Reis, Thaila Fernanda [UNESP]
dc.contributor.authorde Souza-Neto, Francisco Nunes
dc.contributor.authorGorup, Luiz Fernando
dc.contributor.authorde Camargo, Emerson Rodrigues
dc.contributor.authorBarbosa, Debora Barros [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionApis Flora Industrial e Comercial Ltda
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2022-04-28T19:47:07Z
dc.date.available2022-04-28T19:47:07Z
dc.date.issued2021-11-01
dc.description.abstractInfected cutaneous ulcers from diabetic rats with Candida albicans and Streptococcus aureus were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant S. aureus reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques’ limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included.en
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationLaboratory of Research Development & Innovation Apis Flora Industrial e Comercial Ltda
dc.description.affiliationDepartment of Chemistry Federal University of São Carlos
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2016/04230-9
dc.identifierhttp://dx.doi.org/10.3390/antibiotics10111343
dc.identifier.citationAntibiotics, v. 10, n. 11, 2021.
dc.identifier.doi10.3390/antibiotics10111343
dc.identifier.issn2079-6382
dc.identifier.scopus2-s2.0-85118916073
dc.identifier.urihttp://hdl.handle.net/11449/222842
dc.language.isoeng
dc.relation.ispartofAntibiotics
dc.sourceScopus
dc.subjectCandida albicans
dc.subjectNanoparticles
dc.subjectPunica granatum
dc.subjectSilver
dc.subjectStaphylococcus aureus
dc.subjectWound healing
dc.titleGreen and chemical silver nanoparticles and pomegranate formulations to heal infected wounds in diabetic ratsen
dc.typeArtigo
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