Low back pain, obesity, and inflammatory markers: exercise as potential treatment

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Cruz Fernandes, Isabela Maia da [UNESP]
Pinto, Rafael Zambelli
Ferreira, Paulo
Lira, Fabio Santos [UNESP]

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Korean Soc Exercise Rehabilitation


Low back pain is a health issue with significant impact to patients and society. This narrative review aims to synthesize the relationship between obesity, low-grade inflammation and low back pain. It is known that a sedentary lifestyle is a risk factor for obesity and related disorders. The adipose tissue of obese people secretes a range of cytokines of character pro-and anti-inflammatory, with many molecular effects. In addition, pro-inflammatory cytokines are sensitizers of C-reactive protein (CRP), a marker of acute inflammation that can be linked to the musculoskeletal pain sensation individuals with back pain. Another inflammatory marker deserves mention, prostaglandin E-2. Prostaglandin E-2 is important in the process of triggering actions such as pyrexia, sen-sation of pain and inflammation, which are exhibited in low back pain condition. The potential for exercises and physical activity to control these mediators and act as a preventative measure for back pain are important because they work as a nonpharmacological strategy to this target audience. There are two types of exercise discussed in this review, the moderate-intensity continuous training and high-intensity interval training.



Low back pain, Obesity, Sedentary lifestyle, C-reactive protein, Prostaglandins

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Journal Of Exercise Rehabilitation. Seoul: Korean Soc Exercise Rehabilitation, v. 14, n. 2, p. 168-174, 2018.