Synthesis of azo carbonate monomers and biocompatibility study of poly(azo-carbonate-urethane)s

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dc.contributor.authorCapitao, R. M. [UNESP]
dc.contributor.authorSanto, R. D. E. [UNESP]
dc.contributor.authorMagalhaes, A.
dc.contributor.authorAssis, D.
dc.contributor.authorSilva, G. V. J. da
dc.contributor.authorScarim, C. B. [UNESP]
dc.contributor.authorChelucci, R. C. [UNESP]
dc.contributor.authorAndrade, C. R. [UNESP]
dc.contributor.authorChung, M. C. [UNESP]
dc.contributor.authorGonzalez, E. R. P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionBruker Brasil
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-11-26T17:04:30Z
dc.date.available2018-11-26T17:04:30Z
dc.date.issued2016-01-01
dc.description.abstractThe present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of similar to 98% to bis-carbonates after only six minutes of reaction using triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2. The copolymers' structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, Campus Presidente Prudente,CP 467, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Programa Posgrad Ciencia & Tecnol Mat POSMAT, Sao Paulo, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Inst Quim, Dept Quim Inorgan, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationBruker Brasil, BR-12954260 Atibaia, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ave Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Med, Campus Araraquara, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol, Dept Fisiol & Patol, Campus Araraquara, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, Campus Presidente Prudente,CP 467, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Programa Posgrad Ciencia & Tecnol Mat POSMAT, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Med, Campus Araraquara, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol, Dept Fisiol & Patol, Campus Araraquara, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2013/24487-6
dc.format.extent79987-79997
dc.identifierhttp://dx.doi.org/10.1039/c6ra11075d
dc.identifier.citationRsc Advances. Cambridge: Royal Soc Chemistry, v. 6, n. 83, p. 79987-79997, 2016.
dc.identifier.doi10.1039/c6ra11075d
dc.identifier.fileWOS000382539600082.pdf
dc.identifier.issn2046-2069
dc.identifier.lattes9734333607975413
dc.identifier.lattes2402682969776875
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.orcid0000-0001-7015-7175
dc.identifier.urihttp://hdl.handle.net/11449/161877
dc.identifier.wosWOS:000382539600082
dc.language.isoeng
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofRsc Advances
dc.relation.ispartofsjr0,863
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleSynthesis of azo carbonate monomers and biocompatibility study of poly(azo-carbonate-urethane)sen
dc.typeArtigo
dcterms.rightsHolderRoyal Soc Chemistry
unesp.author.lattes9734333607975413[9]
unesp.author.lattes2402682969776875[8]
unesp.author.orcid0000-0003-4141-0455[9]
unesp.author.orcid0000-0001-7015-7175[8]
unesp.departmentFísica, Química e Biologia - FCTpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Presidente Prudente - FCT - Faculdade de Ciências e Tecnologia
Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Artigos - Fisiologia e Patologia - FOAR