Synthesis of azo carbonate monomers and biocompatibility study of poly(azo-carbonate-urethane)s
dc.contributor.author | Capitao, R. M. [UNESP] | |
dc.contributor.author | Santo, R. D. E. [UNESP] | |
dc.contributor.author | Magalhaes, A. | |
dc.contributor.author | Assis, D. | |
dc.contributor.author | Silva, G. V. J. da | |
dc.contributor.author | Scarim, C. B. [UNESP] | |
dc.contributor.author | Chelucci, R. C. [UNESP] | |
dc.contributor.author | Andrade, C. R. [UNESP] | |
dc.contributor.author | Chung, M. C. [UNESP] | |
dc.contributor.author | Gonzalez, E. R. P. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
dc.contributor.institution | Bruker Brasil | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2018-11-26T17:04:30Z | |
dc.date.available | 2018-11-26T17:04:30Z | |
dc.date.issued | 2016-01-01 | |
dc.description.abstract | The present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of similar to 98% to bis-carbonates after only six minutes of reaction using triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2. The copolymers' structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses. | en |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, Campus Presidente Prudente,CP 467, BR-19060900 Presidente Prudente, SP, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Programa Posgrad Ciencia & Tecnol Mat POSMAT, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Campinas UNICAMP, Inst Quim, Dept Quim Inorgan, BR-13083970 Campinas, SP, Brazil | |
dc.description.affiliation | Bruker Brasil, BR-12954260 Atibaia, SP, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ave Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Med, Campus Araraquara, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Fac Odontol, Dept Fisiol & Patol, Campus Araraquara, Sao Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, Campus Presidente Prudente,CP 467, BR-19060900 Presidente Prudente, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Programa Posgrad Ciencia & Tecnol Mat POSMAT, Sao Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Med, Campus Araraquara, Sao Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Odontol, Dept Fisiol & Patol, Campus Araraquara, Sao Paulo, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | FAPESP: 2013/24487-6 | |
dc.format.extent | 79987-79997 | |
dc.identifier | http://dx.doi.org/10.1039/c6ra11075d | |
dc.identifier.citation | Rsc Advances. Cambridge: Royal Soc Chemistry, v. 6, n. 83, p. 79987-79997, 2016. | |
dc.identifier.doi | 10.1039/c6ra11075d | |
dc.identifier.file | WOS000382539600082.pdf | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.lattes | 9734333607975413 | |
dc.identifier.lattes | 2402682969776875 | |
dc.identifier.orcid | 0000-0003-4141-0455 | |
dc.identifier.orcid | 0000-0001-7015-7175 | |
dc.identifier.uri | http://hdl.handle.net/11449/161877 | |
dc.identifier.wos | WOS:000382539600082 | |
dc.language.iso | eng | |
dc.publisher | Royal Soc Chemistry | |
dc.relation.ispartof | Rsc Advances | |
dc.relation.ispartofsjr | 0,863 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.title | Synthesis of azo carbonate monomers and biocompatibility study of poly(azo-carbonate-urethane)s | en |
dc.type | Artigo | |
dcterms.rightsHolder | Royal Soc Chemistry | |
unesp.author.lattes | 9734333607975413[9] | |
unesp.author.lattes | 2402682969776875[8] | |
unesp.author.orcid | 0000-0003-4141-0455[9] | |
unesp.author.orcid | 0000-0001-7015-7175[8] | |
unesp.department | Física, Química e Biologia - FCT | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |
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