Perinatal exposure to parasiticide ivermectin: Long-term effects on reproductive parameters of adult male rats

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dc.contributor.authorTerneux, Eduardo Wladimir Avilés [UNESP]
dc.contributor.authorPontes, Davi Abeid
dc.contributor.authorFernandez, Carla Dal Bianco
dc.contributor.authorArena, Arielle Cristina
dc.contributor.authorPorto, Elaine Manoela
dc.contributor.authorde Kempinas, Wilma Grava [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal da Grande Dourados (UFGD)
dc.date.accessioned2014-05-27T11:25:28Z
dc.date.available2014-05-27T11:25:28Z
dc.date.issued2011-02-01
dc.description.abstractIvermectin is one of the most widely used antiparasitic drugs globally. The aim of this study was to evaluate the chronic effects of perinatal exposure to ivermectin on male reproductive parameters in rats. Pregnant rats were treated daily by oral gavage with 0.4 or 1.6 mg kg -1 of ivermectin or vehicle, from gestational day 6 until post-natal day 10. In the adulthood stage, there were significant reductions in the relative testicular weight of rats exposed to the low dose and in relative prostate weight of male rats exposed to the high dose of ivermectin. Furthermore, the animals exposed to the low dose also presented an increased seminal vesicle weight compared to controls. However, neither of the ivermectin doses interfered in daily sperm production, sperm number in testis, or sexual behavior of exposed males. In conclusion, perinatal exposure to ivermectin neither altered the male reproductive system development markedly, nor produced any adverse effects on the parameters evaluated. © 2011 Taylor & Francis.en
dc.description.affiliationDepartamento de Morfologia Instituto de Biociências Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.description.affiliationPrograma de Pós-graduação em Biologia Celular e Estrutural Instituto de Biologia Universidade Estadual de Campinas-UNICAMP, Campinas, SP
dc.description.affiliationFaculdade de Ciências da Saúde Universidade Federal da Grande Dourados-UFGD, Dourados, MS
dc.description.affiliationUnespDepartamento de Morfologia Instituto de Biociências Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.format.extent345-351
dc.identifierhttp://dx.doi.org/10.1080/02772248.2010.523930
dc.identifier.citationToxicological and Environmental Chemistry, v. 93, n. 2, p. 345-351, 2011.
dc.identifier.doi10.1080/02772248.2010.523930
dc.identifier.issn0277-2248
dc.identifier.issn1029-0486
dc.identifier.lattes0729220781785349
dc.identifier.scopus2-s2.0-78649828380
dc.identifier.urihttp://hdl.handle.net/11449/72301
dc.language.isoeng
dc.relation.ispartofToxicological and Environmental Chemistry
dc.relation.ispartofjcr0.972
dc.relation.ispartofsjr0,313
dc.relation.ispartofsjr0,313
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectGestation
dc.subjectIvermectin
dc.subjectMale reproductive system
dc.subjectParasiticide
dc.subjectRat
dc.subjectAdverse effect
dc.subjectAntiparasitic drugs
dc.subjectChronic effects
dc.subjectHigh dose
dc.subjectLong-term effects
dc.subjectLow dose
dc.subjectMale rats
dc.subjectPregnant rat
dc.subjectReproductive systems
dc.subjectSeminal vesicle
dc.subjectAnimals
dc.subjectRats
dc.subjectdevelopmental biology
dc.subjectdose-response relationship
dc.subjectivermectin
dc.subjectmale
dc.subjectpollution effect
dc.subjectpollution exposure
dc.subjectpregnancy
dc.subjectreproductive strategy
dc.subjectrodent
dc.subjectsecondary sexual characteristics
dc.subjectsperm
dc.subjectAnimalia
dc.subjectRattus
dc.titlePerinatal exposure to parasiticide ivermectin: Long-term effects on reproductive parameters of adult male ratsen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
unesp.author.lattes0729220781785349[4]
unesp.author.orcid0000-0002-2373-9399[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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