Changes in lipid composition in hippocampus early and late after status epilepticus induced by kainic acid in wistar rats

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dc.contributor.authorDal-Pizzol, Felipe
dc.contributor.authorQuevedo, Joao
dc.contributor.authorStreck, Emilio
dc.contributor.authorWalz, Roger
dc.contributor.authorMoreira, Jose Claudio F.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.date.accessioned2014-05-20T15:29:59Z
dc.date.available2014-05-20T15:29:59Z
dc.date.issued2007-03-01
dc.description.abstractOxidative damage to biological membranes has been reported as a cause of alterations in many different diseases. We had previously reported lipid peroxidation in the kainic acid model of temporal epilepsy. In this study we evaluated earlier and later modifications in the lipid composition after status epileticus induced by kainic acid. Lipid composition was determined by thin-layer chromatography, in the cortex and hippocampus 12-14 h, 7-8, 75-80, or 140-150 days after the end of status epileticus. In the hippocampus there was a significant change in the lipid protein ratio after status epileticus and this was accompanied by an alteration in lipid composition in all tested times. These results suggested that lipid peroxidation induced by kainic acid could be accompanied by chronic changes in the lipid composition that could be related to the development of seizures.en
dc.description.affiliationUNESP, Programa Posgrad Ciências Saude, Lab Fisiopatol Expt, BR-88006000 Circiuma, SC, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Dept Clin Med, BR-88040900 Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Ctr Estudos Estresse Oxidat, Dept Bioquim, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationUnespUNESP, Programa Posgrad Ciências Saude, Lab Fisiopatol Expt, BR-88006000 Circiuma, SC, Brazil
dc.format.extent25-29
dc.identifierhttp://dx.doi.org/10.1007/s11011-006-9033-2
dc.identifier.citationMetabolic Brain Disease. New York: Springer/plenum Publishers, v. 22, n. 1, p. 25-29, 2007.
dc.identifier.doi10.1007/s11011-006-9033-2
dc.identifier.issn0885-7490
dc.identifier.urihttp://hdl.handle.net/11449/39439
dc.identifier.wosWOS:000246370800003
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMetabolic Brain Disease
dc.relation.ispartofjcr2.441
dc.relation.ispartofsjr0,909
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectoxidative stresspt
dc.subjectkainic acidpt
dc.subjectseizurespt
dc.subjectlipid peroxidationpt
dc.subjectlipid compositionpt
dc.subjectmembrane fluiditypt
dc.titleChanges in lipid composition in hippocampus early and late after status epilepticus induced by kainic acid in wistar ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0002-9875-6687[4]
unesp.author.orcid0000-0003-3114-6611[2]
unesp.author.orcid0000-0003-3003-8977[1]
unesp.author.orcid0000-0002-2859-4678[3]

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