Inflammation in neurocysticercosis: clinical relevance and impact on treatment decisions

dc.contributor.authorHamamoto Filho, Pedro T [UNESP]
dc.contributor.authorFragoso, Gladis
dc.contributor.authorSciutto, Edda
dc.contributor.authorFleury, Agnès
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad Nacional Autónoma de México
dc.contributor.institutionInstituto Nacional de Neurología Y Neurocirugía
dc.contributor.institutionInstituto de Investigaciones Biomédicas-Universidad Nacional Autónoma de México/INNN/Facultad de Medicina-UNAM
dc.date.accessioned2021-06-25T10:57:57Z
dc.date.available2021-06-25T10:57:57Z
dc.date.issued2021-01-01
dc.description.abstractIntroduction: Neurocysticercosis is caused by the localization of Taenia solium larvae in the central nervous system. The disease remains endemic in most countries of Latin America, Asia and Africa. While major improvements have been made in its diagnosis and treatment, uncertainties persist regarding the clinical implications and treatment of the inflammatory reaction associated with the disease. Areas covered: In this review, based on PubMed searches, the authors describe the characteristics of the immune-inflammatory response in patients with neurocysticercosis, its clinical implications and the treatment currently administered. The dual role of inflammation (participating in both, the death of the parasite, and the precipitation of serious complications) is discussed. New therapeutic strategies of potential interest are presented. Expert opinion: Inflammatory reaction is the main pathogenic mechanism associated to neurocysticercosis. Its management is mainly based on corticosteroids administration. This strategy had improved prognostic of patients as it allows for the control of most of the inflammatory complications. On the other side, it might be involved in the persistence of parasites in some patients, despite cysticidal treatment, due to its immunosuppressive properties. New strategies are needed to improve therapeutical management, particularly in the severest presentations.en
dc.description.affiliationDepartment of Neurology Psychology and Psychiatry UNESP-Univ Estadual Paulista Botucatu Medical School
dc.description.affiliationDepartment of Immunology Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México
dc.description.affiliationDepartment of Genomic Medicine and Environmental Toxicology Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México
dc.description.affiliationNeurocysticercosis Clinic Instituto Nacional de Neurología Y Neurocirugía
dc.description.affiliationNeuroinflammation Unit Instituto de Investigaciones Biomédicas-Universidad Nacional Autónoma de México/INNN/Facultad de Medicina-UNAM
dc.description.affiliationUnespDepartment of Neurology Psychology and Psychiatry UNESP-Univ Estadual Paulista Botucatu Medical School
dc.identifierhttp://dx.doi.org/10.1080/14787210.2021.1912592
dc.identifier.citationExpert Review of Anti-Infective Therapy.
dc.identifier.doi10.1080/14787210.2021.1912592
dc.identifier.issn1744-8336
dc.identifier.issn1478-7210
dc.identifier.scopus2-s2.0-85104245113
dc.identifier.urihttp://hdl.handle.net/11449/207605
dc.language.isoeng
dc.relation.ispartofExpert Review of Anti-Infective Therapy
dc.sourceScopus
dc.subjectAnti-inflammatory drugs
dc.subjectcorticosteroids
dc.subjectinflammation
dc.subjectneurocysticercosis
dc.subjectneuroinflammation
dc.subjectparasite
dc.subjecttaenia solium
dc.titleInflammation in neurocysticercosis: clinical relevance and impact on treatment decisionsen
dc.typeResenha
unesp.author.orcid0000-0001-6436-9307[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentNeurologia, Psicologia e Psiquiatria - FMBpt

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