Inflammation in neurocysticercosis: clinical relevance and impact on treatment decisions
dc.contributor.author | Hamamoto Filho, Pedro T [UNESP] | |
dc.contributor.author | Fragoso, Gladis | |
dc.contributor.author | Sciutto, Edda | |
dc.contributor.author | Fleury, Agnès | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidad Nacional Autónoma de México | |
dc.contributor.institution | Instituto Nacional de Neurología Y Neurocirugía | |
dc.contributor.institution | Instituto de Investigaciones Biomédicas-Universidad Nacional Autónoma de México/INNN/Facultad de Medicina-UNAM | |
dc.date.accessioned | 2021-06-25T10:57:57Z | |
dc.date.available | 2021-06-25T10:57:57Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | Introduction: Neurocysticercosis is caused by the localization of Taenia solium larvae in the central nervous system. The disease remains endemic in most countries of Latin America, Asia and Africa. While major improvements have been made in its diagnosis and treatment, uncertainties persist regarding the clinical implications and treatment of the inflammatory reaction associated with the disease. Areas covered: In this review, based on PubMed searches, the authors describe the characteristics of the immune-inflammatory response in patients with neurocysticercosis, its clinical implications and the treatment currently administered. The dual role of inflammation (participating in both, the death of the parasite, and the precipitation of serious complications) is discussed. New therapeutic strategies of potential interest are presented. Expert opinion: Inflammatory reaction is the main pathogenic mechanism associated to neurocysticercosis. Its management is mainly based on corticosteroids administration. This strategy had improved prognostic of patients as it allows for the control of most of the inflammatory complications. On the other side, it might be involved in the persistence of parasites in some patients, despite cysticidal treatment, due to its immunosuppressive properties. New strategies are needed to improve therapeutical management, particularly in the severest presentations. | en |
dc.description.affiliation | Department of Neurology Psychology and Psychiatry UNESP-Univ Estadual Paulista Botucatu Medical School | |
dc.description.affiliation | Department of Immunology Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México | |
dc.description.affiliation | Department of Genomic Medicine and Environmental Toxicology Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México | |
dc.description.affiliation | Neurocysticercosis Clinic Instituto Nacional de Neurología Y Neurocirugía | |
dc.description.affiliation | Neuroinflammation Unit Instituto de Investigaciones Biomédicas-Universidad Nacional Autónoma de México/INNN/Facultad de Medicina-UNAM | |
dc.description.affiliationUnesp | Department of Neurology Psychology and Psychiatry UNESP-Univ Estadual Paulista Botucatu Medical School | |
dc.identifier | http://dx.doi.org/10.1080/14787210.2021.1912592 | |
dc.identifier.citation | Expert Review of Anti-Infective Therapy. | |
dc.identifier.doi | 10.1080/14787210.2021.1912592 | |
dc.identifier.issn | 1744-8336 | |
dc.identifier.issn | 1478-7210 | |
dc.identifier.scopus | 2-s2.0-85104245113 | |
dc.identifier.uri | http://hdl.handle.net/11449/207605 | |
dc.language.iso | eng | |
dc.relation.ispartof | Expert Review of Anti-Infective Therapy | |
dc.source | Scopus | |
dc.subject | Anti-inflammatory drugs | |
dc.subject | corticosteroids | |
dc.subject | inflammation | |
dc.subject | neurocysticercosis | |
dc.subject | neuroinflammation | |
dc.subject | parasite | |
dc.subject | taenia solium | |
dc.title | Inflammation in neurocysticercosis: clinical relevance and impact on treatment decisions | en |
dc.type | Resenha | |
unesp.author.orcid | 0000-0001-6436-9307[1] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu | pt |
unesp.department | Neurologia, Psicologia e Psiquiatria - FMB | pt |