Influence of Taurine on Cardiac Remodeling Induced by Tobacco Smoke Exposure

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dc.contributor.authorDenipote, Fabiana [UNESP]
dc.contributor.authorArdisson, Lidiane P. [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorLima-Leopoldo, Ana P. [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorPolegato, Bertha Furlan [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorNovelli, Ethel [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:50:53Z
dc.date.available2014-05-20T13:50:53Z
dc.date.issued2011-01-01
dc.description.abstractBackground/Aims: To investigate the effect of taurine on cardiac remodeling induced by smoking. Methods: In the first step, rats were allocated into two groups: Group C (n=14): control; Group T (n=14): treated with taurine (3% in drinking water), for three months. In the second step, rats were allocated into two groups: Group ETS (n=9): rats exposed to tobacco smoke; Group ETS-T (n=9): rats exposed to tobacco smoke and treated with taurine for two months. Results: After three months, taurine presented no effects on morphological or functional variables of normal rats assessed by echocardiogram. on the other hand, after two months, ETS-T group presented higher LV wall thickness (ETS=1.30 (1.20-1.42); ETS-T=1.50 (1.40-1.50); p=0.029), E/A ratio (ETS=1.13 +/- 0.13; ETS-T=1.37 +/- 0.26; p=0.028), and isovolumetric relaxation time normalized for heart rate (ETS=53.9 +/- 4.33; ETS-T=72.5 +/- 12.0; p<0.001). The cardiac activity of the lactate dehydrogenase was higher in the ETS-T group (ETS=204 +/- 14 nmol/mg protein; ETS-T=232 +/- 12 nmol/mg protein; p<0.001). ETS-T group presented lower levels of phospholamban (ETS=1.00 +/- 0.13; ETS-T=0.82 +/- 0.06; p=0.026), phosphorylated phospholamban at Ser16 (ETS=1.00 +/- 0.14;ETS-T=0.63 +/- 0.10;p=0.003), and phosphorylated phosfolamban/phospholamban ratio (ETS=1.01 +/- 0.17; ETS-T=0.77 +/- 0.11; p=0.050). Conclusion: In normal rats, taurine produces no effects on cardiac morphological or functional variables. on the other hand, in rats exposed to cigarette smoke, taurine supplementation increases wall thickness and worsens diastolic function, associated with alterations in calcium handling protein and cardiac energy metabolism. Copyright (C) 2011 S. Karger AG, Baselen
dc.description.affiliationUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biosci, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biosci, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 Botucatu, SP, Brazil
dc.format.extent291-298
dc.identifierhttp://dx.doi.org/10.1159/000327955
dc.identifier.citationCellular Physiology and Biochemistry. Basel: Karger, v. 27, n. 3-4, p. 291-298, 2011.
dc.identifier.doi10.1159/000327955
dc.identifier.fileWOS000290594900013.pdf
dc.identifier.issn1015-8987
dc.identifier.lattes6990977122340795
dc.identifier.lattes6309835137998766
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/18154
dc.identifier.wosWOS:000290594900013
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCellular Physiology and Biochemistry
dc.relation.ispartofjcr5.500
dc.relation.ispartofsjr1,561
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectVentricular functionen
dc.subjectSmokingen
dc.subjectHeart failureen
dc.titleInfluence of Taurine on Cardiac Remodeling Induced by Tobacco Smoke Exposureen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/OpenAccessLicense
dcterms.rightsHolderKarger
unesp.author.lattes5016839015394547
unesp.author.lattes6309835137998766
unesp.author.lattes6990977122340795
unesp.author.lattes1213140801402647[3]
unesp.author.lattes7438704034471673
unesp.author.lattes4563764623232492[7]
unesp.author.orcid0000-0003-4412-1990[11]
unesp.author.orcid0000-0002-2875-9532[7]
unesp.author.orcid0000-0002-5980-4367[4]
unesp.author.orcid0000-0002-5843-6232[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Clínica Médica - FMB
Artigos - Microbiologia e Imunologia - IBB
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