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Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics

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dc.contributor.authorNishimoto, I. N.
dc.contributor.authorPinheiro, N. A.
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authorCarvalho, A. L.
dc.contributor.authorSimpson, A. J.
dc.contributor.authorCaballero, O. L.
dc.contributor.authorKowalski, L. P.
dc.contributor.institutionHosp Canc AC Camargo
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:50:08Z
dc.date.available2014-05-20T13:50:08Z
dc.date.issued2004-07-01
dc.description.abstractSquamous cell carcinoma of the upper aerodigestive tract (UADT) is associated with environmental factors, especially tobacco and alcohol consumption. Genetic factors, including cyclin D1 (CCND1) polymorphism have been suggested to play an important rote in tumorigenesis and progression of UADT cancer. To investigate the relationship between CCND1 polymorphism on susceptibility for UADT cancers, 147 cancer and 135 non-cancer subjects were included in this study. CCND1 genotype at codon 242(G870A) in exon 4 was undertaken using denaturing high performance liquid chromatography (DHPLC) and DNA sequencing. Significant odds ratio (OR) of the AA + GA genotypes [OR = 7.5 (95% Cl: 1.4-39.7)] was observed in non-drinkers but for non-smokers a non-significant [OR = 5.4 (95% Cl: 0.9-31.4)] was found in the adjusted model. These results suggest that allele A may be a risk factor for UADT cancer, especially in non-alcoholics. However, further epidemiological studies are needed to establish the exact role of CCND1 polymorphism and the development of UADT cancers. (C) 2004 Elsevier Ltd. All rights reserved.en
dc.description.affiliationHosp Canc AC Camargo, Ctr Tratamento & Pesquisa, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 São Paulo, Brazil
dc.description.affiliationLudwig Inst Canc Res, Canc Genet Lab, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, IB, Dept Genet, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, IB, Dept Genet, Botucatu, SP, Brazil
dc.format.extent604-610
dc.identifierhttp://dx.doi.org/10.1016/j.oraloncology.2003.12.009
dc.identifier.citationOral Oncology. Oxford: Pergamon-Elsevier B.V., v. 40, n. 6, p. 604-610, 2004.
dc.identifier.doi10.1016/j.oraloncology.2003.12.009
dc.identifier.issn1368-8375
dc.identifier.urihttp://hdl.handle.net/11449/17897
dc.identifier.wosWOS:000222229500008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofOral Oncology
dc.relation.ispartofjcr4.636
dc.relation.ispartofsjr1,912
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectUADTpt
dc.subjectCCND1 polymorphismpt
dc.subjectrisk factorpt
dc.subjectcancerpt
dc.subjectupper aerodigestive systempt
dc.titleCyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholicsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentGenética - IBBpt

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Botucatu - IBB - Instituto de Biociências