Pythium insidiosum: inhibitory effects of propolis and geopropolis on hyphal growth

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dc.contributor.authorAraújo, Maria José Abigail Mendes [UNESP]
dc.contributor.authorBosco, Sandra de Moraes Gimenes [UNESP]
dc.contributor.authorSforcin, José Maurício [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:07:45Z
dc.date.available2018-12-11T17:07:45Z
dc.date.issued2016-10-01
dc.description.abstractPropolis and geopropolis are resinous products of bees showing antimicrobial effects. There is no data concerning their action against Pythium insidiosum – the causative agent of pythiosis, a pyogranulomatous disease of the subcutaneous tissue that affects mostly horses, dogs and humans. Fragments of 15 isolates of P. insidiodum were incubated with propolis and geopropolis extracts and evaluated for up to seven days to detect the minimal fungicidal concentration (MFC). Propolis inhibited three isolates at 1.0 mg mL−1 after 24 h and all other isolates at 3.4 mg mL−1. Geopropolis led to more variable results, exerting predominantly a fungistatic action than a fungicidal one. Propolis was more efficient than geopropolis in inhibiting P. insidiosum since lower concentrations led to no growth after 24 h. This effect may be due to propolis chemical composition, which has more active compounds than geopropolis. Propolis seemed to be a good candidate for in vivo studies, since treatment with conventional antifungal compounds is difficult in most of the cases, requiring extensive surgical debridement.en
dc.description.affiliationUnesp Univ Estadual Paulista Instituto de Biociências Departamento de Microbiologia e Imunologia
dc.description.affiliationUnespUnesp Univ Estadual Paulista Instituto de Biociências Departamento de Microbiologia e Imunologia
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2010/01028-8
dc.description.sponsorshipIdFAPESP: 2010/50064-7
dc.format.extent863-869
dc.identifierhttp://dx.doi.org/10.1016/j.bjm.2016.06.008
dc.identifier.citationBrazilian Journal of Microbiology, v. 47, n. 4, p. 863-869, 2016.
dc.identifier.doi10.1016/j.bjm.2016.06.008
dc.identifier.fileS1517-83822016000400863.pdf
dc.identifier.issn1678-4405
dc.identifier.issn1517-8382
dc.identifier.scieloS1517-83822016000400863
dc.identifier.scopus2-s2.0-84994860593
dc.identifier.urihttp://hdl.handle.net/11449/173784
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Microbiology
dc.relation.ispartofsjr0,630
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAfricanized honeybees
dc.subjectGeopropolis
dc.subjectPropolis
dc.subjectPythium insidiosum
dc.subjectStingless bees
dc.titlePythium insidiosum: inhibitory effects of propolis and geopropolis on hyphal growthen
dc.typeArtigo

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