Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells

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dc.contributor.authorMartins, Murillo L. [UNESP]
dc.contributor.authorIgnazzi, Rosanna
dc.contributor.authorEckert, Juergen
dc.contributor.authorWatts, Benjamin
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.authorZambuzzi, Willian F. [UNESP]
dc.contributor.authorDaemen, Luke
dc.contributor.authorSaeki, Margarida J. [UNESP]
dc.contributor.authorBordallo, Heloisa N.
dc.contributor.institutionUniv Copenhagen
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv S Florida
dc.contributor.institutionLos Alamos Natl Lab
dc.contributor.institutionPaul Scherrer Inst
dc.contributor.institutionEuropean Spallat Source ESS AB
dc.date.accessioned2018-11-27T10:20:23Z
dc.date.available2018-11-27T10:20:23Z
dc.date.issued2016-03-02
dc.description.abstractThe most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.en
dc.description.affiliationUniv Copenhagen, Niels Bohr Inst, Blegdamsvej 17, DK-2100 Copenhagen, Denmark
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv S Florida, Dept Chem, 4202 E Fowler Ave, Tampa, FL 33620 USA
dc.description.affiliationLos Alamos Natl Lab, POB 1663, Los Alamos, NM 87545 USA
dc.description.affiliationPaul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland
dc.description.affiliationEuropean Spallat Source ESS AB, POB 176, SE-22100 Lund, Sweden
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipDepartment of Energy's Office of Basic Energy Sciences
dc.description.sponsorshipDOE
dc.description.sponsorshipGerman Minister fur Bildung und Forschung (BMBF)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipDANSCATT
dc.description.sponsorshipIdDOE: DE-AC52-06NA25396
dc.description.sponsorshipIdGerman Minister fur Bildung und Forschung (BMBF): 05KS4WE1/6
dc.description.sponsorshipIdGerman Minister fur Bildung und Forschung (BMBF): 05KS7WE1
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1038/srep22478
dc.identifier.citationScientific Reports. London: Nature Publishing Group, v. 6, 9 p., 2016.
dc.identifier.doi10.1038/srep22478
dc.identifier.fileWOS000371172300001.pdf
dc.identifier.issn2045-2322
dc.identifier.lattes8845835550637809
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.urihttp://hdl.handle.net/11449/165083
dc.identifier.wosWOS:000371172300001
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleRestricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cellsen
dc.typeArtigo
dcterms.rightsHolderNature Publishing Group
unesp.author.lattes8845835550637809[5]
unesp.author.orcid0000-0002-2654-1476[2]
unesp.author.orcid0000-0002-4292-3298[5]

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