Antifungal Action of Herbal Plants’ Glycolic Extracts against Candida Species

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dc.contributor.authorMeccatti, Vanessa Marques [UNESP]
dc.contributor.authorSantos, Lana Ferreira [UNESP]
dc.contributor.authorde Carvalho, Lara Steffany [UNESP]
dc.contributor.authorSouza, Clara Bulhões [UNESP]
dc.contributor.authorCarvalho, Cláudio Antonio Talge [UNESP]
dc.contributor.authorMarcucci, Maria Cristina [UNESP]
dc.contributor.authorAbu Hasna, Amjad [UNESP]
dc.contributor.authorde Oliveira, Luciane Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:10:07Z
dc.date.available2023-07-29T16:10:07Z
dc.date.issued2023-03-01
dc.description.abstractCandida spp. cause fungal infection that affects patients’ oral health. This study aimed to evaluate the isolated and synergistic antifungal effect of Rosa centifolia L., Curcuma longa L., Rosmarinus officinalis L., and Punica granatum L. glycolic extracts against Candida albicans, Candida dubliniensis, Candida tropicalis, and Candida krusei planktonic and biofilm forms. The plant extracts were chemically characterized and the main compounds were quantified by high-performance liquid chromatography (HPLC-DAD) analysis. The minimum inhibitory and minimum fungicidal concentrations of the extracts were determined, and antibiofilm activity was evaluated by MTT assay. Data were analyzed by one-way ANOVA and Tukey’s tests, and by Kruskal–Wallis and Dunn’s tests, considering a significance level of 5%. The main compounds identified in each of the extracts were: p-coumaric acid (2153.22 μg/100 mL) in the rosemary extract, gallotannins (4318.31 μg/100 mL) in the pomegranate extract, quercetin derivatives (3316.50 μg/100 mL) in the extract of white roses, and curcumin (135.09 μg/100 mL) in the turmeric extract. The combination of R. centifolia and C. longa glycolic extracts was effective against C. albicans, C. dubliniensis, and C. tropicalis biofilms over different periods (p < 0.05). The combination of R. officinalis and P. granatum glycolic extracts was effective against C. albicans and C. krusei biofilms after 30 min, and against C. tropicalis after 24 h, with all combinations showing an average reduction of 50% in cell viability (p < 0.05). In conclusion, the combined plant extracts have antifungal and antibiofilm action against Candida spp. in different concentrations and times of action.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), SP
dc.description.affiliationDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), SP
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), SP
dc.description.affiliationUnespDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), SP
dc.description.sponsorshipScientific Research and Technology Development Program of Guangxi
dc.description.sponsorshipIdScientific Research and Technology Development Program of Guangxi: 5344
dc.identifierhttp://dx.doi.org/10.3390/molecules28062857
dc.identifier.citationMolecules, v. 28, n. 6, 2023.
dc.identifier.doi10.3390/molecules28062857
dc.identifier.issn1420-3049
dc.identifier.scopus2-s2.0-85151648637
dc.identifier.urihttp://hdl.handle.net/11449/249823
dc.language.isoeng
dc.relation.ispartofMolecules
dc.sourceScopus
dc.subjectCandida albicans
dc.subjectCandida dubliniensis
dc.subjectCandida krusei
dc.subjectCandida tropicalis
dc.subjectCurcuma longa
dc.subjectPunica granatum
dc.subjectRosa centifolia
dc.subjectRosmarinus
dc.titleAntifungal Action of Herbal Plants’ Glycolic Extracts against Candida Speciesen
dc.typeArtigo
unesp.author.orcid0000-0002-8065-5618[6]
unesp.author.orcid0000-0002-1112-985X[7]

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Artigos - Odontologia Restauradora - ICT