In vitro characterization of coevaporates containing chitosan for colonic drug delivery

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dc.contributor.authorFerrari, Priscileila C. [UNESP]
dc.contributor.authorOliveira, Giselle F. [UNESP]
dc.contributor.authorChibebe, Flavia Cristina S. [UNESP]
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:51Z
dc.date.available2014-05-20T13:24:51Z
dc.date.issued2009-10-15
dc.description.abstractA relative simple drug delivery system in the form of coevaporates were prepared and analyzed. They were based on chitosan (CS), a polysaccharide that undergoes specific degradation by colonic enzymes. Enteric polymers, namely cellulose acetate phtalate (CAP) and hydroxypropylmethylcellulose phtalate (HPMCP), were incorporated, due to their insolubility in environments presenting low pH values. The systems were physically characterized, demonstrating that CS affects the swelling properties of the samples. The ability of these systems to reach the colonic region was assessed in vitro in simulated gastric, enteric and colonic fluids. Korsmeyer-Peppas and Weibull models were applied to analyze the drug release kinetics and the results suggested that the drug release from the coevaporates follows a complex release mechanism, in which several processes, including diffusion, swelling, and erosion. are involved and may occur simultaneously. The results demonstrated that it is possible to prepare relative simple drug carrier systems able to reach the colonic environment, since their swelling capacity can be controlled by varying the composition. (c) 2009 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Grad Program Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Grad Program Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent557-563
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2009.05.021
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier B.V., v. 78, n. 3, p. 557-563, 2009.
dc.identifier.doi10.1016/j.carbpol.2009.05.021
dc.identifier.issn0144-8617
dc.identifier.lattes5361569184579557
dc.identifier.urihttp://hdl.handle.net/11449/7820
dc.identifier.wosWOS:000269991800029
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Polymers
dc.relation.ispartofjcr5.158
dc.relation.ispartofsjr1,428
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectColonic drug deliveryen
dc.subjectChitosanen
dc.subjectCoevaporatesen
dc.subjectMetronidazoleen
dc.titleIn vitro characterization of coevaporates containing chitosan for colonic drug deliveryen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5361569184579557
unesp.author.orcid0000-0002-4285-6646[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR