Performance characteristics of bioassay UV-spectrophotometry and high perfomance liquid chromatographic determination of gatifloxacin in tablets

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dc.contributor.authorLopes, Cristiani Capistrano Gonçalves de Oliveira [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:08Z
dc.date.available2014-05-20T13:25:08Z
dc.date.issued2008-01-01
dc.description.abstractThe microbiological bioassay, UV-spectrophotometry and HPLC methods for assaying gatifloxacin in tablets were compared. Validation parameters such as linearity, precision, accuracy, limit of detection and limit of quantitation were determined. Beer's law was obeyed in the ranges 4.0-14.0 μg/mL for HPLC and UV-spectrophotometric method, and 4.0-16.0 μg/mL for bioassay. All methods were reliable within acceptable limits for antibiotic pharmaceutical preparations being accurate, precise and reproducible. The bioassay and HPLC are more specific than UV-spectrophotometric analysis. The application of each method as a routine analysis should be investigated considering cost, simplicity, equipment, solvents, speed, and application to large or small workloads.en
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos
dc.description.sponsorshipPACD-FCFAr-UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1831-1835
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422008000700039
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1831-1835, 2008.
dc.identifier.doi10.1590/S0100-40422008000700039
dc.identifier.fileS0100-40422008000700039.pdf
dc.identifier.issn0100-4042
dc.identifier.scieloS0100-40422008000700039
dc.identifier.urihttp://hdl.handle.net/11449/7954
dc.identifier.wosWOS:000262432800039
dc.language.isoeng
dc.publisherSociedade Brasileira de Química
dc.relation.ispartofQuímica Nova
dc.relation.ispartofjcr0.646
dc.relation.ispartofsjr0,255
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectfluoroquinoloneen
dc.subjectgatifloxacinen
dc.subjectpharmaceutical analysisen
dc.titlePerformance characteristics of bioassay UV-spectrophotometry and high perfomance liquid chromatographic determination of gatifloxacin in tabletsen
dc.typeArtigo
unesp.author.orcid0000-0002-8120-2362[1]
unesp.author.orcid0000-0002-0385-340X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas