Eriodictyol Suppresses Porphyromonas gingivalis-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophages

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dc.contributor.authorMaquera-Huacho, Patricia Milagros [UNESP]
dc.contributor.authorSpolidorio, Denise Palomari [UNESP]
dc.contributor.authorManthey, John. A. A.
dc.contributor.authorGrenier, Daniel
dc.contributor.institutionUniv Laval
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUSDA
dc.date.accessioned2023-07-29T12:00:51Z
dc.date.available2023-07-29T12:00:51Z
dc.date.issued2022-02-28
dc.description.abstractPorphyromonas gingivalis is a key pathogen of periodontitis, an inflammatory disease that affects the tooth-supporting tissues. The aim of the present study was to investigate the effects of the flavanone eriodictyol on P. gingivalis-induced reactive oxygen species (ROS) production by gingival keratinocytes and the inflammatory response of macrophages. Porphyromonas gingivalis and H2O2 acted synergistically to induce ROS production by keratinocytes. The presence of eriodictyol significantly attenuated ROS production in a dose-dependent manner. We used a macrophage model to show that eriodictyol decreases the secretion of IL-1 beta, IL-6, IL-8, and TNF-alpha induced by P. gingivalis. Evidence has been brought that this anti-inflammatory property of eriodictyol may be related to its ability to prevent the activation of the NF-kappa B signaling pathway by P. gingivalis. This periodontal pathogen was also found to be a potent inducer of matrix metalloproteinase (MMP) production by macrophages, including MMP-2, MMP-8, and MMP-9. Eriodictyol dose-dependently inhibited the production of all three MMPs. Lastly, eriodictyol inhibited the catalytic activity of both MMP-9 and P. gingivalis collagenase. In conclusion, eriodictyol may be a potential therapeutic agent for preventing and/or treating periodontal disease due to its antioxidant, anti-inflammatory, and anti-proteinase properties.en
dc.description.affiliationUniv Laval, Fac Dent, Oral Ecol Res Grp, Quebec City, PQ, Canada
dc.description.affiliationSao Paulo State Univ Unesp, Sch Dent, Dept Physiol & Pathol, Araraquara, Brazil
dc.description.affiliationUSDA, US Hort Res Lab, Agr Res Serv, Ft Pierce, FL USA
dc.description.affiliationUnespSao Paulo State Univ Unesp, Sch Dent, Dept Physiol & Pathol, Araraquara, Brazil
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.3389/froh.2022.847914
dc.identifier.citationFrontiers in Oral Health. Lausanne: Frontiers Media Sa, v. 3, 10 p., 2022.
dc.identifier.doi10.3389/froh.2022.847914
dc.identifier.urihttp://hdl.handle.net/11449/245643
dc.identifier.wosWOS:000993703800001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Oral Health
dc.sourceWeb of Science
dc.subjecteriodictyol
dc.subjectmacrophage
dc.subjectkeratinocyte
dc.subjectPorphyromonas gingivalis
dc.subjectperiodontal disease
dc.titleEriodictyol Suppresses Porphyromonas gingivalis-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophagesen
dc.typeArtigo
dcterms.rightsHolderFrontiers Media Sa

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