Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III

dc.contributor.authorSteffens, Joao Paulo [UNESP]
dc.contributor.authorWang, Xiaoshan
dc.contributor.authorStarr, Jacqueline R.
dc.contributor.authorSpolidorio, Luis Carlos [UNESP]
dc.contributor.authorVan Dyke, Thomas E.
dc.contributor.authorKantarci, Alpdogan
dc.contributor.institutionForsyth Inst
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHarvard Univ
dc.contributor.institutionUniv Washington
dc.date.accessioned2018-11-26T16:17:05Z
dc.date.available2018-11-26T16:17:05Z
dc.date.issued2015-10-01
dc.description.abstractBackground: Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). Methods: Data from 755 men (aged >= 30 years), including serum levels of testosterone, estradiol, sex hormone binding globulin, and androstenediol glucuronide, were analyzed. Calculated bioavailable testosterone (CBT) and estradiol-to-testosterone ratio were calculated. Periodontitis was defined using the latest classification of extent and severity of periodontitis for NHANES data (>= 2 interproximal sites with >= 3 mm attachment loss, >= 2 interproximal sites with probing depth [PD] >= 4 mm not on the same tooth, or one site with PD >= 5 mm). Sex hormones were evaluated as categorized and continuous variables. Correlations between the presence and severity of periodontitis and levels of sex hormones were determined and expressed as odds ratios (ORs). Results: When adjusted for confounding factors, high total testosterone (TT) and CBT levels correlated with both the prevalence (OR [95% confidence interval (CI)], 2.1 [1 to 4.5] and 3.9 [1 to 14.8], respectively) and severity (OR [95% CI], 2.1 [1 to 4.3] and 3.4 [1.2 to 9.8]) of periodontitis. When continuous variables were used, the ORs (95% CIs) for presence and severity of periodontitis were 1.4 (0.6 to 3.3) and 1.5 (0.6 to 3.6) for TT and 1.3 (0.9 to 1.9) and 1.3 (0.9 to 1.8) for CBT, respectively. Conclusions: These findings are consistent with the existence of an association of periodontitis with sex hormone levels, especially testosterone, in men.en
dc.description.affiliationForsyth Inst, Ctr Periodontol, Dept Appl Oral Sci, Cambridge, MA USA
dc.description.affiliationUniv Estadual Paulista, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationHarvard Univ, Sch Dent Med, Dept Oral Hlth Policy & Epidemiol, Boston, MA 02115 USA
dc.description.affiliationUniv Washington, Dept Epidemiol, Seattle, WA 98195 USA
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNational Institutes of Health/National Institute of Dental and Craniofacial Research
dc.description.sponsorshipIdFAPESP: 2010/09658-0
dc.description.sponsorshipIdFAPESP: 2010/12021-4
dc.description.sponsorshipIdCAPES: 5258-11-1
dc.description.sponsorshipIdCNPq: 470870/2011-7
dc.description.sponsorshipIdNational Institutes of Health/National Institute of Dental and Craniofacial Research: DE015566
dc.description.sponsorshipIdNational Institutes of Health/National Institute of Dental and Craniofacial Research: DE020906
dc.format.extent1116-1125
dc.identifierhttp://dx.doi.org/10.1902/jop.2015.140530
dc.identifier.citationJournal Of Periodontology. Chicago: Amer Acad Periodontology, v. 86, n. 10, p. 1116-1125, 2015.
dc.identifier.doi10.1902/jop.2015.140530
dc.identifier.issn0022-3492
dc.identifier.lattes2640929291808415
dc.identifier.urihttp://hdl.handle.net/11449/160872
dc.identifier.wosWOS:000362045200003
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal Of Periodontology
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAndrogens
dc.subjectcross-sectional studies
dc.subjectgonadal steroid hormones
dc.subjectinflammation
dc.subjectperiodontitis
dc.subjecttestosterone
dc.titleAssociations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES IIIen
dc.typeArtigo
dcterms.rightsHolderAmer Acad Periodontology
unesp.author.lattes2640929291808415
unesp.author.orcid0000-0002-0592-542X[4]

Arquivos