The role of moderate-to-vigorous physical activity in mediating the relationship between central adiposity and immunometabolic profile in postmenopausal women

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dc.contributor.authorDiniz, Tiego A. [UNESP]
dc.contributor.authorRossi, Fabricio E. [UNESP]
dc.contributor.authorSilveira, Loreana S. [UNESP]
dc.contributor.authorNeves, Lucas Melo
dc.contributor.authorde Souza Fortaleza, Ana Claudia [UNESP]
dc.contributor.authorChristofaro, Diego G. D. [UNESP]
dc.contributor.authorLira, Fabio S. [UNESP]
dc.contributor.authorFreitas-Junior, Ismael F. [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:49:43Z
dc.date.available2018-12-11T16:49:43Z
dc.date.issued2017-08-01
dc.description.abstractObjectives: To analyze the role of moderate-to-vigorous physical activity (MVPA) in mediating the relationship between central adiposity and immune and metabolic profile in postmenopausal women. Materials and methods: Cross-sectional study comprising 49 postmenopausal women (aged 59.26 ± 8.32 years) without regular physical exercise practice. Body composition was measured by dual-energy X-ray absorptiometry. Fasting blood samples were collected for assessment of nonesterified fatty acids, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), adiponectin, insulin and estimation of insulin resistance (HOMA-IR). Physical activity level was assessed with an accelerometer (Actigraph GTX3x) and reported as a percentage of time spent in sedentary behavior and MVPA. All analyses were performed using the software SPSS 17.0, with a significance level set at 5%. Results: Sedentary women had a positive relationship between trunk fat and IL-6 (rho = 0.471; p = 0.020), and trunk fat and HOMA-IR (rho = 0.418; p = 0.042). Adiponectin and fat mass (%) were only positively correlated in physically active women (rho = 0.441; p = 0.027). Physically active women with normal trunk fat values presented a 14.7% lower chance of having increased HOMA-IR levels (β [95%CI] = 0.147 [0.027; 0.811]). Conclusions: The practice of sufficient levels of MVPA was a protective factor against immunometabolic disorders in postmenopausal women.en
dc.description.affiliationUniversidade de São Paulo (USP)
dc.description.affiliationGrupo de Imunometabolismo e Exercício Departamento de Educação Física Universidade Estadual Paulista (Unesp)
dc.description.affiliationCentro de Estudos e Laboratório de Avaliação e Prescrição de Atividades Motoras (Celapam) Departamento de Educação Física Unesp
dc.description.affiliationGrupo de Estudos em Atividade Física e Saúde Departamento de Educação Física Unesp
dc.description.affiliationUnespGrupo de Imunometabolismo e Exercício Departamento de Educação Física Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespCentro de Estudos e Laboratório de Avaliação e Prescrição de Atividades Motoras (Celapam) Departamento de Educação Física Unesp
dc.description.affiliationUnespGrupo de Estudos em Atividade Física e Saúde Departamento de Educação Física Unesp
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent354-360
dc.identifierhttp://dx.doi.org/10.1590/2359-3997000000259
dc.identifier.citationArchives of Endocrinology and Metabolism, v. 61, n. 4, p. 354-360, 2017.
dc.identifier.doi10.1590/2359-3997000000259
dc.identifier.fileS2359-39972017000400354.pdf
dc.identifier.issn2359-4292
dc.identifier.issn2359-3997
dc.identifier.scieloS2359-39972017000400354
dc.identifier.scopus2-s2.0-85029836524
dc.identifier.urihttp://hdl.handle.net/11449/170197
dc.language.isoeng
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.relation.ispartofsjr0,505
dc.relation.ispartofsjr0,505
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAdiponectin
dc.subjectAdipose tissue
dc.subjectCytokines
dc.subjectInsulin resistance
dc.subjectObesity
dc.subjectPostmenopause
dc.titleThe role of moderate-to-vigorous physical activity in mediating the relationship between central adiposity and immunometabolic profile in postmenopausal womenen
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