Malignancy prediction of cutaneous and subcutaneous neoplasms in canines using B-mode ultrasonography, Doppler, and ARFI elastography

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dc.contributor.authorda Cruz, Igor Cezar Kniphoff [UNESP]
dc.contributor.authorCarneiro, Rafael Kretzer [UNESP]
dc.contributor.authorde Nardi, Andrigo Barboza [UNESP]
dc.contributor.authorUscategui, Ricardo Andrés Ramirez
dc.contributor.authorBortoluzzi, Eduarda Mazzardo
dc.contributor.authorFeliciano, Marcus Antônio Rossi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidad CES
dc.contributor.institutionUniversidade Federal do Vale do Jequitinhonha e Mucuri
dc.contributor.institutionKansas State University
dc.contributor.institutionUniversidade Federal de Santa Maria
dc.date.accessioned2022-04-28T19:48:56Z
dc.date.available2022-04-28T19:48:56Z
dc.date.issued2022-12-01
dc.description.abstractBackground: Cutaneous and subcutaneous neoplasms are highly prevalent in dogs, ranging from benign to highly aggressive and metastatic lesions. The diagnosis is obtained through histopathology, however it is an invasive technique that may take a long time to obtain the result, delaying the beginning of the adequate treatment. Thus, there is a need for non-invasive tests that can help in the early diagnosis of this type of cancer. The aim of this study was to verify the accuracy of B-mode ultrasonography, Doppler, and ARFI elastography to predict malignancy in cutaneous and subcutaneous canine neoplasms. In addition, we aim to propose an ultrasonography evaluation protocol and perform the neoplasms characterization using these three proposed techniques. Results: Twenty-one types of specific neoplasm were diagnosed, and using B-mode, we verified the association between heterogeneous echotexture, invasiveness, presence of hyperechoic spots, and cavity areas with malignancy. An increased pulsatility was verified in malignant neoplasms using Doppler (cut-off value > 0.93). When using the elastography, malignancy was associated with non-deformable tissues and shear wave velocity > 3.52 m/s. Evaluation protocols were proposed associating 4, 5, 6, or 7 malignancy predictive characteristics, and characterization was done for all tumors with at least two cases. Conclusions: We concluded that ultrasonography methods are promising and effective in predicting malignancy in these types of tumors, and the association of methods can increase the specificity of the results.en
dc.description.affiliationUniversidade Estadual Paulista “Júlio de Mesquita Filho”, Via de acesso Professor Paulo Donato Castellane, s/n, Vila Industrial
dc.description.affiliationUniversidad CES
dc.description.affiliationUniversidade Federal do Vale do Jequitinhonha e Mucuri
dc.description.affiliationKansas State University
dc.description.affiliationUniversidade Federal de Santa Maria
dc.description.affiliationUnespUniversidade Estadual Paulista “Júlio de Mesquita Filho”, Via de acesso Professor Paulo Donato Castellane, s/n, Vila Industrial
dc.identifierhttp://dx.doi.org/10.1186/s12917-021-03118-y
dc.identifier.citationBMC Veterinary Research, v. 18, n. 1, 2022.
dc.identifier.doi10.1186/s12917-021-03118-y
dc.identifier.issn1746-6148
dc.identifier.scopus2-s2.0-85122221250
dc.identifier.urihttp://hdl.handle.net/11449/223158
dc.language.isoeng
dc.relation.ispartofBMC Veterinary Research
dc.sourceScopus
dc.subjectCancer
dc.subjectCanine
dc.subjectOncology
dc.subjectUltrasonography
dc.titleMalignancy prediction of cutaneous and subcutaneous neoplasms in canines using B-mode ultrasonography, Doppler, and ARFI elastographyen
dc.typeArtigo

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