Insights on the role of cytokines in carious lesions

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dc.contributor.authorGonçalves, Lucélia Lemes [UNESP]
dc.contributor.authorKim, Eui
dc.contributor.authorBortolatto, Janaína Freitas
dc.contributor.authorBuzalaf, Marilia Rabello
dc.contributor.authorAlreshaid, Lulwah
dc.contributor.authorPrakki, Anuradha
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionRestorative Department
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCollege of Dentistry
dc.date.accessioned2023-07-29T13:42:03Z
dc.date.available2023-07-29T13:42:03Z
dc.date.issued2023-01-01
dc.description.abstractObjectives: The dentin-pulp immune response to caries pathogenesis is still poorly understood due to the complex interplay of the involving processes. The aim of this review was to explore the role of cytokines and its relevance in the pathogenesis of dental caries. Results: Dental caries can result in a host inflammatory response in the dental pulp, characterized by the accumulation of inflammatory cells leading to the release of inflammatory cytokines such as Interleukin-4 (IL-4), Interleukin (IL-6), Interleukin-8 (IL-8) and Tumor necrosis factor–α (TNF-α). IL-4 seems to be correlated to the depth of carious lesions; IL-6 is strongly correlated to caries disease and is considered a potent biomarker; IL-8 can be a potent biomarker for both caries and other changes present in the pulp and, its release is correlated to TNF-α and IL-6; TNF-α plays an important role not only in caries progression, but also in other pathological processes. Conclusion: Specific mediators have a great potential to serve as biomarkers alluding to the presence and progress of caries disease, urging further investigations in the field.en
dc.description.affiliationUniversidade Estadual de Sao Paulo Instituto de Ciencias e Tecnologia de Sao Jose dos Campos Departamento de Dentistica Restauradora, SP
dc.description.affiliationUniversity of Toronto Faculty of Dentistry Restorative Department
dc.description.affiliationUniversidade de Sao Paulo Faculdade de Odontologia de Bauru Departamento de Ciencias Biologicas, SP
dc.description.affiliationKing Saud bin Abdulaziz University for Health Sciences College of Dentistry Department of Restorative Dental Sciences
dc.description.affiliationUnespUniversidade Estadual de Sao Paulo Instituto de Ciencias e Tecnologia de Sao Jose dos Campos Departamento de Dentistica Restauradora, SP
dc.identifierhttp://dx.doi.org/10.4322/bds.2023.e3666
dc.identifier.citationBrazilian Dental Science, v. 26, n. 1, 2023.
dc.identifier.doi10.4322/bds.2023.e3666
dc.identifier.issn2178-6011
dc.identifier.scopus2-s2.0-85148224581
dc.identifier.urihttp://hdl.handle.net/11449/248365
dc.language.isoeng
dc.relation.ispartofBrazilian Dental Science
dc.sourceScopus
dc.subjectBiomarkers
dc.subjectCytokines
dc.subjectDental caries
dc.subjectDental pulp
dc.subjectInterleukins
dc.titleInsights on the role of cytokines in carious lesionsen
dc.titleInsights sobre o papel das citocinas em lesões cariosaspt
dc.typeResenha

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Artigos - Odontologia Restauradora - ICT