Activity of Sodium Trimetaphosphate Nanoparticles on Cariogenic-Related Biofilms In Vitro

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dc.contributor.authorAmarante, Viviane de Oliveira Zequini [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.authorSampaio, Caio [UNESP]
dc.contributor.authorde Morais, Leonardo Antônio [UNESP]
dc.contributor.authorde Camargo, Emerson Rodrigues
dc.contributor.authorMonteiro, Douglas Roberto [UNESP]
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorHosida, Thayse Yumi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.date.accessioned2023-07-29T16:02:34Z
dc.date.available2023-07-29T16:02:34Z
dc.date.issued2023-01-01
dc.description.abstractIn light of the promising effect of sodium trimetaphosphate nanoparticles (TMPn) on dental enamel, in addition to the scarce evidence of the effects of these nanoparticles on biofilms, this study evaluated the activity of TMPn with/without fluoride (F) on the pH, inorganic composition and extracellular matrix (ECM) components of dual-species biofilms of Streptococcus mutans and Candida albicans. The biofilms were cultivated in artificial saliva in microtiter plates and treated with solutions containing 1% or 3% conventional/microparticulate TMP (TMPm) or TMPn, with or without F. After the last treatment, the protein and carbohydrate content of the ECM was analyzed, and the pH and F, calcium (Ca), phosphorus (P), and TMP concentrations of the biofilms were determined. In another set of experiments, after the last treatment, the biofilms were exposed to a 20% sucrose solution, and their matrix composition, pH, and inorganic component contents were evaluated. 3% TMPn/F significantly reduced ECM carbohydrate and increased biofilm pH (after sucrose exposure) than other treatments. Also, it significantly increased P and F levels before sucrose exposure in comparison to 3% TMPm/F. In conclusion, 3% TMPn/F affected the biofilm ECM and pH, besides influencing inorganic biofilm composition by increasing P and F levels in the biofilm fluid.en
dc.description.affiliationDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.description.affiliationDepartment of Chemistry Federal University of São Carlos (UFSCar), SP
dc.description.affiliationPostgraduate Program in Health Sciences University of Western São Paulo (UNOESTE), SP
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.identifierhttp://dx.doi.org/10.3390/nano13010170
dc.identifier.citationNanomaterials, v. 13, n. 1, 2023.
dc.identifier.doi10.3390/nano13010170
dc.identifier.issn2079-4991
dc.identifier.scopus2-s2.0-85145833399
dc.identifier.urihttp://hdl.handle.net/11449/249540
dc.language.isoeng
dc.relation.ispartofNanomaterials
dc.sourceScopus
dc.subjectbiofilms
dc.subjectCandida albicans
dc.subjectdental caries
dc.subjectextracellular matrix
dc.subjectfluorides
dc.subjectnanotechnology
dc.subjectphosphates
dc.subjectStreptococcus mutans
dc.titleActivity of Sodium Trimetaphosphate Nanoparticles on Cariogenic-Related Biofilms In Vitroen
dc.typeArtigo
unesp.author.orcid0000-0002-8159-4853[2]
unesp.author.orcid0000-0001-5229-5259[6]
unesp.author.orcid0000-0002-1550-3933[7]

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Artigos - Odontologia Infantil e Social - FOA