Effect of nonsteroidal anti-inflammatory drugs (NSAIDs) association on physicochemical and biological properties of tricalcium silicate-based cement

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dc.contributor.authorOliveira, Maria Carolina Guiotti de
dc.contributor.authorQueiroz, Índia Olinta de Azevedo
dc.contributor.authorMachado, Thiago [UNESP]
dc.contributor.authorGarrido, Lorena de Mello Alcântara
dc.contributor.authorOliveira, Sandra Helena Penha de [UNESP]
dc.contributor.authorDuarte, Marco Antonio Hungaro
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T20:54:05Z
dc.date.available2023-03-01T20:54:05Z
dc.date.issued2022-05-01
dc.description.abstractThe aim of this study was to investigate the physicochemical and biological properties of an experimental tricalcium silicate-based repair cement containing diclofenac sodium (CERD). For the physicochemical test, MTA, Biodentine and CERD were mixed and cement disc were prepared to evaluate the setting time and radiopacity. Root-end cavity were performed in acrylic teeth and filled with cements to analyze the solubility up to 7 days. Polyethylene tubes containing cements were prepared and calcium ions and pH were measured at 3h, 24h, 72h and 15 days. For the biological test, SAOS-2 were cultivated, exposed to cements extracts and cell proliferation were investigated by MTT assay at 6h, 24h and 48h. Polyethylene tubes containing cements were implanted into Wistar rats. After 7 and 30 days, the tubes were removed and processed for histological analyses. Parametric and nonparametric data were performed. No difference was identified in relation to setting time, radiopacity and solubility. Biodentine released more calcium ion than MTA and CERD; however, no difference between MTA and CERD were detected. Alkaline pH was observed for all cements and Biodentine exhibited highest pH. All cements promoted a raise on cell proliferation at 24h and 48h, except CERD at 48h. Biodentine stimulated cell metabolism in relation to MTA and CERD while CERD was more cytotoxic than MTA at 48h. Besides, no difference on both inflammatory response and mineralization ability for all cement were found. CERD demonstrated similar proprieties to others endodontic cements available.en
dc.description.affiliationDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry USP
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery and Integrated Clinic Araçatuba Dental School UNESP
dc.description.affiliationDepartment of Basic Science Araçatuba Dental School UNESP
dc.description.affiliationUnespDepartment of Oral and Maxillofacial Surgery and Integrated Clinic Araçatuba Dental School UNESP
dc.description.affiliationUnespDepartment of Basic Science Araçatuba Dental School UNESP
dc.format.extent47-54
dc.identifierhttp://dx.doi.org/10.1590/0103-6440202204644
dc.identifier.citationBrazilian dental journal, v. 33, n. 3, p. 47-54, 2022.
dc.identifier.doi10.1590/0103-6440202204644
dc.identifier.issn1806-4760
dc.identifier.scopus2-s2.0-85133214420
dc.identifier.urihttp://hdl.handle.net/11449/241261
dc.language.isoeng
dc.relation.ispartofBrazilian dental journal
dc.sourceScopus
dc.titleEffect of nonsteroidal anti-inflammatory drugs (NSAIDs) association on physicochemical and biological properties of tricalcium silicate-based cementen
dc.typeArtigo
unesp.author.orcid0000-0002-0073-005X[1]
unesp.author.orcid0000-0001-8214-0880[2]
unesp.author.orcid0000-0002-5245-2629[3]
unesp.author.orcid0000-0002-7201-1505[4]
unesp.author.orcid0000-0003-0805-1120[5]
unesp.author.orcid0000-0003-3051-737X[6]

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Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Ciências Básicas - FOA