Investigation of thermal degradation products of mebendazole by thermal and spectroscopic analysis

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dc.contributor.authorHolanda, Bruno B.C. [UNESP]
dc.contributor.authorAlarcon, Rafael T. [UNESP]
dc.contributor.authorGuerra, Renan B. [UNESP]
dc.contributor.authorRinaldo, Daniel [UNESP]
dc.contributor.authorSpazzini, Fabiola C.R. [UNESP]
dc.contributor.authorCastro, Ricardo A.E.
dc.contributor.authorBannach, Gilbert [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCollege of Pharmacy
dc.date.accessioned2019-10-06T16:51:30Z
dc.date.available2019-10-06T16:51:30Z
dc.date.issued2018-10-01
dc.description.abstractIn this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved gas analysis (EGA), and DSC-photovisual analysis were employed to fully evaluate the polymorphic form A of MBZ. Our results showed that mebendazole undergoes mass loss starting at 205 °C with the release of methanol and carbon monoxide. Characterization of the main thermal decomposition product of MBZ through mid-infrared spectroscopy (MIR), proton nuclear magnetic resonance ( 1 H NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and powder X-ray diffraction (PXRD) indicated the formation of 2-amino-5-benzoylbenzimidazole (MBZ-A). Kinetic parameters for MBZ and MBZ-A were also evaluated and shown herein.en
dc.description.affiliationUNESP - São Paulo State University School of Sciences Chemistry Department
dc.description.affiliationCoimbra University College of Pharmacy
dc.description.affiliationUnespUNESP - São Paulo State University School of Sciences Chemistry Department
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2017/08820-8
dc.description.sponsorshipIdFAPESP: 2018/03460-6
dc.description.sponsorshipIdCNPq: 302267/2015-8
dc.format.extent76-84
dc.identifierhttp://dx.doi.org/10.1016/j.jaap.2018.09.017
dc.identifier.citationJournal of Analytical and Applied Pyrolysis, v. 135, p. 76-84.
dc.identifier.doi10.1016/j.jaap.2018.09.017
dc.identifier.issn0165-2370
dc.identifier.scopus2-s2.0-85054002940
dc.identifier.urihttp://hdl.handle.net/11449/189766
dc.language.isoeng
dc.relation.ispartofJournal of Analytical and Applied Pyrolysis
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCoupled TG-FTIR
dc.subjectDSC-photovisual analysis
dc.subjectMebendazole
dc.subjectThermal behavior
dc.titleInvestigation of thermal degradation products of mebendazole by thermal and spectroscopic analysisen
dc.typeArtigo
unesp.departmentQuímica - FCpt

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Bauru - FC - Faculdade de Ciências