Publicação:
DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy

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dc.contributor.authorMinicucci, E. M. [UNESP]
dc.contributor.authorRibeiro, D. A.
dc.contributor.authorde Camargo, B.
dc.contributor.authorCosta, M. C.
dc.contributor.authorRibeiro, Lúcia Regina [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAC Camargo Hosp
dc.date.accessioned2014-05-20T13:37:34Z
dc.date.available2014-05-20T13:37:34Z
dc.date.issued2008-06-01
dc.description.abstractThe aim of the present study was to evaluate DNA damage (micronucleus) in cytokinesis-blocked lymphocytes and exfoliated buccal mucosa cells from children with malignant tumours and under chemotherapy. Micronucleated cells (MNCs) were assessed from children before and during chemotherapy. A total of 21 healthy children (controls), matched for gender and age, were used as control. The results pointed out higher frequencies of micronucleated lymphocytes in children with malignant tumour before any therapy when compared to healthy probands. Furthermore an increase of micronucleated lymphocytes during chemotherapy was detected when compared to the data obtained before chemotherapy. No statistically significant increases of MNCs were noticed in buccal mucosa cells at any of the timepoints evaluated. Taken together, these data indicate that the presence of malignant tumours may increase the frequency of DNA damage in circulating lymphocytes, these cells being more sensitive for detecting chromosome aberrations caused by anti-cancer drugs.en
dc.description.affiliationUNESP, Botucatu Med Sch, Fac Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed São Paulo, UNIFESP, Dept Hlth Sci, Santos, SP, Brazil
dc.description.affiliationAC Camargo Hosp, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Botucatu Med Sch, Fac Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent79-85
dc.identifierhttp://dx.doi.org/10.1007/s10238-008-0161-3
dc.identifier.citationClinical and Experimental Medicine. New York: Springer, v. 8, n. 2, p. 79-85, 2008.
dc.identifier.doi10.1007/s10238-008-0161-3
dc.identifier.issn1591-8890
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/13022
dc.identifier.wosWOS:000257022600004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofClinical and Experimental Medicine
dc.relation.ispartofjcr2.787
dc.relation.ispartofsjr0,848
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBuccal mucosa cellsen
dc.subjectChemotherapyen
dc.subjectCytokinesis-block micronucleus assayen
dc.subjectPaediatric canceren
dc.titleDNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapyen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[6]
unesp.author.orcid0000-0002-5794-1042[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentPatologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina