Perioperative central venous oxygen saturation and its correlation with mortality during cardiac surgery: an observational prospective study

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dc.contributor.authorMiranda, César de Araujo
dc.contributor.authorMeletti, José F.A.
dc.contributor.authorLima, Laís H.N. [UNESP]
dc.contributor.authorMarchi, Evaldo
dc.contributor.institutionDisciplina de Anestesiologia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de Jundiaí
dc.date.accessioned2020-12-12T02:20:36Z
dc.date.available2020-12-12T02:20:36Z
dc.date.issued2020-01-01
dc.description.abstractBackground: Cardiac surgery can produce persistent deficit in the ratio of Oxygen Delivery (DO2) to Oxygen Consumption (VO2). Central venous oxygen Saturation (ScvO2) is an accessible and indirect measure of DO2/VO2 ratio. Objective: To monitor perioperative ScvO2 and assess its correlation with mortality during cardiac surgery. Methods: This prospective observational study evaluated 273 patients undergoing cardiac surgery. Blood gas samples were collected to measure ScvO2 at three time points: T0 (after anesthetic induction), T1 (end of surgery), and T2 (24 hours after surgery). The patients were divided into two groups (survivors and nonsurvivors). The following outcomes were analyzed: intrahospital mortality, length of Intensive Care Unit (ICU) and hospital stay (LOS), and variation in ScvO2. Results: Of the 273 patients, 251 (92%) survived and 22 (8%) did not. There was a significant perioperative reduction of ScvO2 in both survivors (T0 = 78% ± 8.1%, T1 = 75.4% ± 7.5%, and T2 = 68.5% ± 9%; p < 0.001) and nonsurvivors (T0 = 74.4% ± 8.7%, T1 = 75.4% ± 7.7%, and T2 = 66.7% ± 13.1%; p < 0.001). At T0, the percentage of patients with ScvO2 < 70% was greater in the nonsurvivor group (31.8% vs. 13.1%; p = 0.046) and the multiple logistic regression showed that ScvO2 is an independent risk factor associated with death, OR = 2.94 (95% CI 1.10 − 7.89) (p = 0.032). The length of ICU and LOS were 3.6 ± 3.1 and 7.4 ± 6.0 days respectively and was not significantly associated with ScvO2. Conclusions: Early intraoperative ScvO2 < 70% indicated a higher risk of death. A perioperative reduction of ScvO2 was observed in patients undergoing cardiac surgery, with high intraoperative and lower postoperative levels.en
dc.description.affiliationFaculdade de Medicina de Jundiaí Disciplina de Anestesiologia
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Anestesiologia
dc.description.affiliationFaculdade de Medicina de Jundiaí
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Anestesiologia
dc.identifierhttp://dx.doi.org/10.1016/j.bjan.2020.04.014
dc.identifier.citationBrazilian Journal of Anesthesiology.
dc.identifier.doi10.1016/j.bjan.2020.04.014
dc.identifier.issn1806-907X
dc.identifier.issn0034-7094
dc.identifier.scopus2-s2.0-85089960607
dc.identifier.urihttp://hdl.handle.net/11449/200962
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBrazilian Journal of Anesthesiology
dc.sourceScopus
dc.subjectBlood gas analyses
dc.subjectCardiac surgery procedures
dc.subjectMortality
dc.subjectPerioperative care
dc.subjectVenous catheterization
dc.titlePerioperative central venous oxygen saturation and its correlation with mortality during cardiac surgery: an observational prospective studyen
dc.titleCorrelação entre saturação venosa central de oxigênio perioperatória e mortalidade em cirurgia cardíaca: estudo prospectivo observacionalpt
dc.typeArtigo
unesp.author.orcid0000-0002-2062-6110[1]
unesp.author.orcid0000-0002-0225-2258[2]
unesp.author.orcid0000-0001-9596-7289[3]
unesp.author.orcid0000-0003-2131-5514[4]

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Artigos - Anestesiologia - FMB