Facilitation of sodium intake by combining noradrenaline into the lateral parabrachial nucleus with prazosin peripherally

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dc.contributor.authorGasparini, S. [UNESP]
dc.contributor.authorGomide, J. M C [UNESP]
dc.contributor.authorAndrade-Franzé, G. M F [UNESP]
dc.contributor.authorTotola, L. T.
dc.contributor.authorDe Luca, L. A. [UNESP]
dc.contributor.authorColombari, Débora Simões de Almeida [UNESP]
dc.contributor.authorPaula, Patricia Maria de [UNESP]
dc.contributor.authorMoreira, T. S.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:30:47Z
dc.date.available2014-05-27T11:30:47Z
dc.date.issued2013-10-01
dc.description.abstractInjections of noradrenaline into the lateral parabrachial nucleus (LPBN) increase arterial pressure and 1.8% NaCl intake and decrease water intake in rats treated with the diuretic furosemide (FURO) combined with a low dose of the angiotensin converting enzyme inhibitor captopril (CAP). In the present study, we investigated the influence of the pressor response elicited by noradrenaline injected into the LPBN on FURO + CAP-induced water and 1.8% NaCl intake. Male Holtzman rats with bilateral stainless steel guide-cannulas implanted into LPBN were used. Bilateral injections of noradrenaline (40 nmol/0.2 μl) into the LPBN increased FURO + CAP-induced 1.8% NaCl intake (12.2 ± 3.5, vs., saline: 4.2 ± 0.8 ml/180 min), reduced water intake and strongly increased arterial pressure (50 ± 7, vs. saline: 1 ± 1 mm Hg). The blockade of the α1 adrenoceptors with the prazosin injected intraperitoneally abolished the pressor response and increased 1.8% NaCl and water intake in rats treated with FURO + CAP combined with noradrenaline injected into the LPBN. The deactivation of baro and perhaps volume receptors due to the cardiovascular effects of prazosin is a mechanism that may facilitate water and NaCl intake in rats treated with FURO + CAP combined with noradrenaline injected into the LPBN. Therefore, the activation of α2 adrenoceptors with noradrenaline injected into the LPBN, at least in dose tested, may not completely remove the inhibitory signals produced by the activation of the cardiovascular receptors, particularly the signals that result from the extra activation of these receptors with the increase of arterial pressure. © 2013 Elsevier Inc.en
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry São Paulo State University, UNESP, Araraquara, São Paulo
dc.description.affiliationDepartment of Physiology and Biophysics Institute of Biomedical Science University of São Paulo-USP, São Paulo, SP
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry São Paulo State University, UNESP, Araraquara, São Paulo
dc.format.extent111-119
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2013.08.017
dc.identifier.citationPharmacology Biochemistry and Behavior, v. 111, p. 111-119.
dc.identifier.doi10.1016/j.pbb.2013.08.017
dc.identifier.issn0091-3057
dc.identifier.issn1873-5177
dc.identifier.lattes0201361251312074
dc.identifier.lattes1023597870118105
dc.identifier.orcid0000-0001-5433-4493
dc.identifier.scopus2-s2.0-84884659449
dc.identifier.urihttp://hdl.handle.net/11449/76733
dc.identifier.wosWOS:000326991400017
dc.language.isoeng
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBaro and volume receptors
dc.subjectBlood pressure
dc.subjectNoradrenaline
dc.subjectParabrachial nucleus
dc.subjectSodium appetite
dc.titleFacilitation of sodium intake by combining noradrenaline into the lateral parabrachial nucleus with prazosin peripherallyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes0201361251312074[7]
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-5433-4493[7]
unesp.author.orcid0000-0003-1167-4441[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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