Role of resistance physical exercise in preventing testicular damage caused by chronic ethanol consumption in UChB rats

dc.contributor.authorDutra Gonçalves, Gessica
dc.contributor.authorAntunes Vieira, Nichelle
dc.contributor.authorRodrigues Vieira, Henrique
dc.contributor.authorDias Valério, Aline
dc.contributor.authorElóisa Munhoz de Lion Siervo, Gláucia
dc.contributor.authorFernanda Felipe Pinheiro, Patricia [UNESP]
dc.contributor.authorEduardo Martinez, Francisco [UNESP]
dc.contributor.authorAlessandra Guarnier, Flávia
dc.contributor.authorRampazzo Teixeira, Giovana [UNESP]
dc.contributor.authorScantamburlo Alves Fernandes, Glaura
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:08:19Z
dc.date.available2018-12-11T17:08:19Z
dc.date.issued2017-04-01
dc.description.abstractEthanol consumption is associated with spermatogenesis damage and testosterone level alterations. Alcohol remains the most commonly used substance among athletes and sports enthusiasts. This study evaluated whether resistance physical exercise can reduce the testicular damage caused by ethanol exposure. A total of 36 ethanol drinking (UChB) rats were divided into four groups: C (control rats), ETOH (ethanol consumption), ETOH + T (ethanol consumption + physical training), and T (group physical training). The physical training component of the T and ETOH + T groups was based on a resistance training model consisting of four sets of 10 jumps, with an increasing overload of 50–70% of the body weight attached to the chest three times per week. Rats in the ETOH and ETOH +T groups received 10% ethanol. At postnatal day 90, the rats were sacrificed. Blood sample was collected for hormonal analysis, and the testicles were weighed and processed for histopathological, morphometric, and immunohistochemical analyses. The ETOH group showed an increase in testosterone levels. The immunohistochemical of androgen receptor and the absolute weight of the testes were higher in the ETOH and ETOH + T groups, while the ETOH animals showed a decreased weight gain index. The number of abnormal seminiferous tubules increased in the ETOH and T groups compared to those in the control group (C); however, the association with treatment (ETOH + T group) prevented this effect and decreased caspase-3 production. In conclusion, these findings show that the combination of ethanol consumption and resistance physical exercise can prevent testicular damage in adult UChB rats.en
dc.description.affiliationDepartment of General Biology Biological Sciences Center State University of Londrina – UEL
dc.description.affiliationDepartment of General Pathology Biological Sciences Center State University of Londrina – UEL
dc.description.affiliationDepartment of Anatomy Biosciences Institute University Paulista Presidente Prudente (UNESP)
dc.description.affiliationDepartment of Physical Education Center of Science and Technology University Paulista Presidente Prudente (UNESP) Educational Center, 305
dc.description.affiliationUnespDepartment of Anatomy Biosciences Institute University Paulista Presidente Prudente (UNESP)
dc.description.affiliationUnespDepartment of Physical Education Center of Science and Technology University Paulista Presidente Prudente (UNESP) Educational Center, 305
dc.format.extent378-386
dc.identifierhttp://dx.doi.org/10.1002/jemt.22806
dc.identifier.citationMicroscopy Research and Technique, v. 80, n. 4, p. 378-386, 2017.
dc.identifier.doi10.1002/jemt.22806
dc.identifier.issn1097-0029
dc.identifier.issn1059-910X
dc.identifier.scopus2-s2.0-85006056401
dc.identifier.urihttp://hdl.handle.net/11449/173915
dc.language.isoeng
dc.relation.ispartofMicroscopy Research and Technique
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectethanol
dc.subjectresistance physical exercise
dc.subjecttestes
dc.subjectUChB rats
dc.titleRole of resistance physical exercise in preventing testicular damage caused by chronic ethanol consumption in UChB ratsen
dc.typeArtigo

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