TOXIC EFFECTS OF WATER EUTROPHICATION ON PANCREATIC, HEPATIC AND OSTEOGENIC TISSUES OF RATS

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dc.contributor.authorNovelli, ELB
dc.contributor.authorValente, JPS
dc.contributor.authorRodrigues, N. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:32Z
dc.date.available2014-05-20T15:26:32Z
dc.date.issued1994-10-01
dc.description.abstractPollution, industrial solvents, concentrations of metals and other environmental agents are widely related to biochemicals values which are used in disease diagnosis of environmental toxicity. A rat bioassay validated for the identification of toxic effects of eutrophication revealed increased serum activities of amylase, alanine transaminase (BLT) and alkaline phosphatase (ALP) in rats that received algae, filtered water and nickel or cadmium from drinking water. Serum Cu-Zn superoxide dismutase activity decreased from its basal level of 40.8 +/- 2.3 to 26.4 U/mg protein, at 7 days of algae and at 48 hr of nickel and cadmium water ingestion. The observation that lipoperoxide concentration was not altered in rats treated with filtered water, while amylase, ALT and ALP were increased in these rats and in those treated with nickel or cadmium, indicated that pancreatic, hepatic and osteogenic lesions by eutrophication were not related to superoxide radicals, and might be due to a novel toxic environmental agent found in filtered and non-filtered algae water.en
dc.description.affiliationUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT QUIM,DISCIPLINA BIOQUIM,BR-18618000 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT QUIM,DISCIPLINA BIOQUIM,BR-18618000 BOTUCATU,SP,BRAZIL
dc.format.extent1270-1274
dc.identifierhttp://dx.doi.org/10.1016/0041-0101(94)90357-3
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 32, n. 10, p. 1270-1274, 1994.
dc.identifier.doi10.1016/0041-0101(94)90357-3
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/11449/36692
dc.identifier.wosWOS:A1994PK38900011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleTOXIC EFFECTS OF WATER EUTROPHICATION ON PANCREATIC, HEPATIC AND OSTEOGENIC TISSUES OF RATSen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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