Blends of poly(3-hydroxybutyrate) and poly(p-dioxanone): miscibility, thermal stability and biocompatibility

dc.contributor.authorDias, Michelle
dc.contributor.authorMoraes Antunes, M. Cecilia
dc.contributor.authorSantos, Arnaldo R. [UNESP]
dc.contributor.authorFelisberti, M. Isabel
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:13:16Z
dc.date.available2014-05-20T13:13:16Z
dc.date.issued2008-12-01
dc.description.abstractThe miscibility, the thermal degradation and biocompatibility of the blends of two biodegradable and bioreabsorbable polymers, brittle polyhydroxybutyric acid (PHB) and flexible poly (p-dioxanone) (PPD) are reported. The blends were prepared by casting from chloroform solutions and analyzed by differential scanning calorimetry, dynamic mechanical analysis, scanning electron microscopy and thermal gravimetric analysis. The blends are immiscible and present promising morphology of a dense phase and a microporous phase, one or the other being the matrix, depending on the composition. Despite the immiscibility, the thermal stability under an inert atmosphere is improved for both polymers. The results obtained from toxicity tests showed that PHB/PPD blends do not present indirect or direct cytotoxicity as a substrate for cellular growth.en
dc.description.affiliationUniv Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUNESP, Fac Ciencias Agr & Vet, Dept Biol Aplicada, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Agr & Vet, Dept Biol Aplicada, Jaboticabal, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent3535-3544
dc.identifierhttp://dx.doi.org/10.1007/s10856-008-3531-1
dc.identifier.citationJournal of Materials Science-materials In Medicine. Dordrecht: Springer, v. 19, n. 12, p. 3535-3544, 2008.
dc.identifier.doi10.1007/s10856-008-3531-1
dc.identifier.issn0957-4530
dc.identifier.urihttp://hdl.handle.net/11449/1122
dc.identifier.wosWOS:000259570800008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Materials Science: Materials in Medicine
dc.relation.ispartofjcr2.448
dc.relation.ispartofsjr0,647
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleBlends of poly(3-hydroxybutyrate) and poly(p-dioxanone): miscibility, thermal stability and biocompatibilityen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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