Genus Paracoccidioides: Species Recognition and Biogeographic Aspects

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dc.contributor.authorTheodoro, Raquel Cordeiro [UNESP]
dc.contributor.authorTeixeira, Marcus de Melo
dc.contributor.authorSoares Felipe, Maria Sueli
dc.contributor.authordos Santos Paduan, Karina [UNESP]
dc.contributor.authorRibolla, Paulo Martins [UNESP]
dc.contributor.authorSan-Blas, Gioconda
dc.contributor.authorBagagli, Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionCtr Microbiol & Cell Biol
dc.date.accessioned2014-05-20T13:52:28Z
dc.date.available2014-05-20T13:52:28Z
dc.date.issued2012-05-30
dc.description.abstractBackground: Paracoccidioidomycosis is a systemic mycosis caused by Paracoccidioides brasiliensis (species S1, PS2, PS3), and Paracoccidioides lutzii. This work aimed to differentiate species within the genus Paracoccidioides, without applying multilocus sequencing, as well as to obtain knowledge of the possible speciation processes.Methodology/Principal Findings: Single nucleotide polymorphism analysis on GP43, ARF and PRP8 intein genes successfully distinguished isolates into four different species. Morphological evaluation indicated that elongated conidia were observed exclusively in P. lutzii isolates, while all other species (S1, PS2 and PS3) were indistinguishable. To evaluate the biogeographic events that led to the current geographic distribution of Paracoccidioides species and their sister species, Nested Clade and Likelihood Analysis of Geographic Range Evolution (LAGRANGE) analyses were applied. The radiation of Paracoccidioides started in northwest South America, around 11-32 million years ago, as calculated on the basis of ARF substitution rate, in the BEAST program. Vicariance was responsible for the divergence among S1, PS2 and P. lutzii and a recent dispersal generated the PS3 species, restricted to Colombia. Taking into account the ancestral areas revealed by the LAGRANGE analysis and the major geographic distribution of L. loboi in the Amazon basin, a region strongly affected by the Andes uplift and marine incursions in the Cenozoic era, we also speculate about the effect of these geological events on the vicariance between Paracoccidioides and L. loboi.Conclusions/Significance: The use of at least 3 SNPs, but not morphological criteria, as markers allows us to distinguish among the four cryptic species of the genus Paracoccidioides. The work also presents a biogeographic study speculating on how these species might have diverged in South America, thus contributing to elucidating evolutionary aspects of the genus Paracoccidioides.en
dc.description.affiliationUniv Estadual Paulista, São Paulo, Brazil
dc.description.affiliationUniv Brasilia UNB, Brasilia, DF, Brazil
dc.description.affiliationCtr Microbiol & Cell Biol, Venezuelan Inst Sci Res, Caracas, Venezuela
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/01306-5
dc.description.sponsorshipIdFAPESP: 10/08839-1
dc.description.sponsorshipIdFAPESP: 10/08829-6
dc.format.extent15
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0037694
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 7, n. 5, p. 15, 2012.
dc.identifier.doi10.1371/journal.pone.0037694
dc.identifier.fileWOS000305353400041.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes3320327570429539
dc.identifier.lattes3577149748456880
dc.identifier.orcid0000-0001-8735-6090
dc.identifier.orcid0000-0002-8003-4109
dc.identifier.urihttp://hdl.handle.net/11449/18741
dc.identifier.wosWOS:000305353400041
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleGenus Paracoccidioides: Species Recognition and Biogeographic Aspectsen
dc.typeArtigo
dcterms.licensehttp://www.plos.org/about/open-access/license/
dcterms.rightsHolderPublic Library Science
unesp.author.lattes3320327570429539[7]
unesp.author.lattes3577149748456880[5]
unesp.author.orcid0000-0001-5016-1046[1]
unesp.author.orcid0000-0002-8003-4109[7]
unesp.author.orcid0000-0001-8735-6090[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB