Pharmacokinetic Study of Nobiletin and Tangeretin in Rat Serum by High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry

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dc.contributor.authorManthey, John A.
dc.contributor.authorCesar, Thais B. [UNESP]
dc.contributor.authorJackson, Erin
dc.contributor.authorMertens-Talcott, Susanne
dc.contributor.institutionARS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTexas A&M Univ
dc.date.accessioned2014-05-20T15:30:27Z
dc.date.available2014-05-20T15:30:27Z
dc.date.issued2011-01-12
dc.description.abstractNobiletin (NOB) and tangeretin (TAN), two of the main polymethoxylated flavones (PMFs) in citrus, influence a number of key biological pathways in mammalian cells. Although the impacts of NOB and TAN on glucose homeostasis and cholesterol regulation have been investigated in human clinical trials, much information is still lacking about the metabolism and oral bioavailability of these compounds in animals. In this study, NOB and TAN were administered to rats by gavage and intraperitoneal (ip) injection, and the blood serum concentrations of these compounds and their main metabolites were monitored by high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). In addition to the administered compounds, two metabolites of TAN and eight metabolites of NOB were detected and measured over 24 h. With identical oral doses, nearly 10-fold higher absorption of NOB occurred compared to TAN. For both compounds, maximum levels of glucuronidated metabolites occurred in the blood serum at later time points (similar to 5-8 h) compared to the earlier T(max) a values for NOB and TAN. In most cases the glucuronides occurred at substantially higher concentrations than the aglycone metabolites. Low levels of NOB and TAN and their metabolites were detectable in rat blood serum even at 24 h after treatment.en
dc.description.affiliationARS, Citrus & Subtrop Prod Res Lab, USDA, Winter Haven, FL 33881 USA
dc.description.affiliationSão Paulo State Univ, Dept Nutr, São Paulo, Brazil
dc.description.affiliationTexas A&M Univ, Dept Nutr & Food Sci, Inst Obes Res & Program Evaluat, College Stn, TX 77845 USA
dc.description.affiliationUnespSão Paulo State Univ, Dept Nutr, São Paulo, Brazil
dc.format.extent145-151
dc.identifierhttp://dx.doi.org/10.1021/jf1033224
dc.identifier.citationJournal of Agricultural and Food Chemistry. Washington: Amer Chemical Soc, v. 59, n. 1, p. 145-151, 2011.
dc.identifier.doi10.1021/jf1033224
dc.identifier.issn0021-8561
dc.identifier.urihttp://hdl.handle.net/11449/39822
dc.identifier.wosWOS:000285735200017
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Agricultural and Food Chemistry
dc.relation.ispartofjcr3.412
dc.relation.ispartofsjr1,269
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNobiletinen
dc.subjecttangeretinen
dc.subjectdemethylnobiletinen
dc.subjectdemethyltangeretinen
dc.subjectpharmacokineticsen
dc.subjectglucuronidesen
dc.subjectmetabolitesen
dc.subjectbioavailabilityen
dc.subjectflavonoidsen
dc.subjectRutaceaeen
dc.titlePharmacokinetic Study of Nobiletin and Tangeretin in Rat Serum by High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometryen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc

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