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Identification of a gene encoding adaptin-like protein in the Paracoccidioides brasiliensis genome by random amplified polymorphic DNA analysis

dc.contributor.authorFerrari Andreotti, Patricia
dc.contributor.authorMonteiro da Silva, Juliana Leal
dc.contributor.authorCristina Teixeira, Elaine
dc.contributor.authorCelia Bertolini, Maria
dc.contributor.authorPienna Soares, Christiane
dc.contributor.authorBenard, Gil
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:36Z
dc.date.available2014-05-20T13:24:36Z
dc.date.issued2007-07-01
dc.description.abstractParacoccidioides brasiliensis isolates are not homogeneous in their patterns of pathogenicity in animals and adhesion to epithelial cells. During this investigation, genotypic differences were observed between two samples of P. brasiliensis strain 18 yeast phase (Pbl 8) previously cultured many times, one taken before (Pb18a) and the other after (Pb18b) animal inoculation. Random amplified polymorphic DNA analysis using the primer OPJ4 distinguished Pb18b from Pbl Ba by one 308 bp DNA fragment, which after cloning and sequencing was shown to encode a polypeptide sequence homologous to the protein beta-adaptin. It is suggested, by comparison to other micro-organisms, that this protein might play an important role in the virulence of P. brasiliensis. This result demonstrates the influence of in vitro subculturing on the genotype of this organism.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Dept Anal Clin, Araraquara, SP, Brazil
dc.description.affiliationUNESP, Inst Quim, Dept Bioquim & Tecnol Quim, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Dermatol, Lab Dermatol & Imunodeficiencias, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Dept Anal Clin, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, Dept Bioquim & Tecnol Quim, Araraquara, SP, Brazil
dc.format.extent884-887
dc.identifierhttp://dx.doi.org/10.1099/jmm.0.47127-0
dc.identifier.citationJournal of Medical Microbiology. Reading: Soc General Microbiology, v. 56, n. 7, p. 884-887, 2007.
dc.identifier.doi10.1099/jmm.0.47127-0
dc.identifier.issn0022-2615
dc.identifier.lattes8817669953838863
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.urihttp://hdl.handle.net/11449/7689
dc.identifier.wosWOS:000247759300002
dc.language.isoeng
dc.publisherSoc General Microbiology
dc.relation.ispartofJournal of Medical Microbiology
dc.relation.ispartofjcr2.112
dc.relation.ispartofsjr0,914
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleIdentification of a gene encoding adaptin-like protein in the Paracoccidioides brasiliensis genome by random amplified polymorphic DNA analysisen
dc.typeArtigo
dcterms.licensehttp://jmm.sgmjournals.org/site/misc/reprints.xhtml
dcterms.rightsHolderSoc General Microbiology
unesp.author.lattes8817669953838863
unesp.author.orcid0000-0002-8059-0826[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentBioquímica e Tecnologia - IQpt

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