Detection of atypical porcine pestivirus in Brazil in the central nervous system of suckling piglets with congenital tremor

dc.contributor.authorGatto, I. R.H. [UNESP]
dc.contributor.authorHarmon, K.
dc.contributor.authorBradner, L.
dc.contributor.authorSilva, P. [UNESP]
dc.contributor.authorLinhares, D. C.L.
dc.contributor.authorArruda, P. H.
dc.contributor.authorde Oliveira, L. G. [UNESP]
dc.contributor.authorArruda, B. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIowa State University
dc.contributor.institutionInc.
dc.date.accessioned2018-12-11T16:51:39Z
dc.date.available2018-12-11T16:51:39Z
dc.date.issued2018-04-01
dc.description.abstractAtypical porcine pestivirus (APPV) has been detected in piglets with congenital tremor (CT) from three different continents including North America, Europe and Asia. Thirteen piglets from four farms in two different states in Brazil with CT were sampled. Viral RNA was detected by quantitative real-time PCR in the cerebellum or cerebellum and spinal cord in the 100% of the piglets with CT, and APPV was not detected in any tissue sample from clinically non-affected piglets with the exception of the cerebellum of one piglet from Farm A. Piglets with CT had an odds ratio of 99.0 (95% CI 3.4, 2823.8; p =.0072) compared to piglets without CT to test positive for APPV by qRT-PCR. A subset of positive samples was selected for sequencing of the NS3 gene. Phylogenetic analysis revealed that Brazilian sequences of the NS3 formed an independent cluster and had the highest sequence identity with a sequence from the United States. This is the first identification of APPV infection in piglets with CT in South America.en
dc.description.affiliationSão Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences Preventive Veterinary Medicine and Animal Reproduction
dc.description.affiliationVeterinary Diagnostic and Production Animal Medicine College of Veterinary Medicine Iowa State University
dc.description.affiliationDepartment of Veterinary Clinics and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)
dc.description.affiliationVeterinary Resources Inc.
dc.description.affiliationUnespSão Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences Preventive Veterinary Medicine and Animal Reproduction
dc.description.affiliationUnespDepartment of Veterinary Clinics and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)
dc.format.extent375-380
dc.identifierhttp://dx.doi.org/10.1111/tbed.12824
dc.identifier.citationTransboundary and Emerging Diseases, v. 65, n. 2, p. 375-380, 2018.
dc.identifier.doi10.1111/tbed.12824
dc.identifier.issn1865-1682
dc.identifier.issn1865-1674
dc.identifier.scopus2-s2.0-85041354807
dc.identifier.urihttp://hdl.handle.net/11449/170604
dc.language.isoeng
dc.relation.ispartofTransboundary and Emerging Diseases
dc.relation.ispartofsjr1,147
dc.relation.ispartofsjr1,147
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectatypical porcine pestivirus
dc.subjectBrazil
dc.subjectcongenital tremor
dc.titleDetection of atypical porcine pestivirus in Brazil in the central nervous system of suckling piglets with congenital tremoren
dc.typeArtigo
unesp.author.orcid0000-0001-5145-8431[6]
unesp.author.orcid0000-0001-7407-9952[8]

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